Regional increases in brain-derived neurotrophic factor and nerve growth factor mRNAs during amygdaloid kindling, but not in acidic and basist growth factor mRNAs

Epilepsia
K SatoT Hayabara

Abstract

We studied mRNA levels for neurotrophic factors using the amygdaloid k indling model of epilepsy. One hour after stage 5 kindled seizures, there were four-to fivefold increases in brain-derived neurotrophic factor (BDNF) mRNA in rat dentate gyrus and perirhinal cortex. Nerve growth factor (NGF) mRNA levels were increased bilaterally in some (but not all) limbic areas. There were no detectable changes in acidic fibroblast GF (aFGF) mRNA or basic fibroblast GF (bFGF) mRNA for 24 h after the kindled seizures. During kindling, levels of BDNF mRNA in the dentate gyrus correlated with projection to generalized seizures, whereas NGF mRNA in the limbic regions continued to increase during seizure development. These results indicate that the induction of mRNAs for neurotrophic factors, especially for BDNF mRNA in the dentate gyrus, corresponds to the increases in metabolic and electrical ictal discharge associated with kindled seizures. The persistent increase observed in NGF mRNA may be related to enhanced synaptic efficacy during kindling, but aFGF and bFGF are presumed to have little relation to the kindling process.

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Citations

Dec 22, 2000·Progress in Neurobiology·J L Jankowsky, P H Patterson
Aug 13, 1998·Seizure : the Journal of the British Epilepsy Association·K MorimotoT Hayabara
Apr 17, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Helen E Scharfman
May 19, 2010·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Kathryn A Giblin, Hal Blumenfeld
Feb 1, 2007·Neuropsychiatric Disease and Treatment·Gerhard Kluger, Bettina Bauer
Mar 23, 2011·Progress in Neurobiology·John Kealy, Sean Commins
Oct 27, 2004·Neuroscience Letters·Kenneth A JenrowKost V Elisevich
Jun 15, 2004·Progress in Neurobiology·Kiyoshi MorimotoRonald J Racine
Jun 10, 2006·Brain Research·Kenneth A JenrowKost V Elisevich

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