Regional infusion-radioembolization

Surgical Oncology Clinics of North America
Gregory J Dubel, Gregory M Soares

Abstract

Selective internal radiation therapy involves the intra-arterial delivery of radioactive beads to the tumor while minimizing dosing to the adjacent organ. Because this technique invariably results in some degree of embolization, it has also been termed radioembolization. More than 8000 patients have been treated worldwide, with a large body of experience with primary hepatocellular carcinoma (HCC) and metastatic colorectal carcinoma (MCRC) and growing experience with other tumors (metastatic neuroendocrine, breast carcinoma, cholangiocarcinoma). Response rates by FDG-PET are 80% to 90%. Complications are uncommon and most often consist of self-limited malaise. More significant complications, including radiation-induced liver disease, ischemic cholecystitis, and gastrointestinal ulceration may be seen in up to 10% of patients. This underscores the critical importance of patient selection and meticulous technique. Median survival times in patients who have HCC and MCRC are significantly improved compared with historic controls. Further study is required to determine the appropriate role of radioembolization in the context of state-of-the-art chemotherapy and other liver-directed therapies.

References

Oct 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J H AndersonC S McArdle
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·T S LawrenceW D Ensminger
Jul 1, 1991·International Journal of Radiation Oncology, Biology, Physics·R A FoxB N Gray
Jun 1, 1989·The British Journal of Surgery·S G Archer, B N Gray
Jan 1, 1987·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·G J Ehrhardt, D E Day
May 1, 1985·Cancer·E J Hall
Mar 1, 1984·The British Journal of Surgery·J M GilbertA E Kark
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·T S LawrenceL F Fajardo
Apr 16, 2002·Seminars in Oncology·Aaron R Sasson, Elin R Sigurdson
Apr 16, 2002·Seminars in Oncology·Milton J Herba, Michael P Thirlwell
May 25, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Ching-yee Oliver WongHoward J Dworkin
Sep 3, 2004·Nature Reviews. Cancer·Jacques BernierAmato Giaccia
Dec 14, 2004·International Journal of Radiation Oncology, Biology, Physics·Andrew S KennedyCinthia Drachenberg
Feb 17, 2005·Journal of Vascular and Interventional Radiology : JVIR·James E GoinKenneth Thurston
Apr 15, 2005·Journal of Gastroenterology·Josep M Llovet
Apr 16, 2005·Clinics in Liver Disease·F Xavier BoschMireia Díaz
May 5, 2005·Cancer Biotherapy & Radiopharmaceuticals·Gabriele PöpperlKlaus Tatsch
Jul 9, 2005·Journal of Vascular and Interventional Radiology : JVIR·David M LiuChing-yee O Wong
Dec 24, 2005·Journal of Vascular and Interventional Radiology : JVIR·Riad SalemKenneth G Thurston
May 13, 2006·International Journal of Radiation Oncology, Biology, Physics·Andrew S KennedyScott Sailer
Aug 15, 2006·International Journal of Radiation Oncology, Biology, Physics·Bruno SangroJesus Prieto
Sep 20, 2006·Acta Oncologica·Joern WulfMichael Flentje
Dec 13, 2006·Nuclear Medicine Communications·Teresa SzyszkoE O'Rourke
Jan 24, 2007·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Mar 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ricky A SharmaWilliam P Steward
May 15, 2007·Journal of Vascular and Interventional Radiology : JVIR·Affaan K BangashRiad Salem
May 23, 2007·Cardiovascular and Interventional Radiology·Robert J LewandowskiRiad Salem
May 26, 2007·International Journal of Radiation Oncology, Biology, Physics·Douglas M ColdwellCharles W Nutting
Oct 4, 2007·Journal of Vascular and Interventional Radiology : JVIR·Lourens Bester, Riad Salem
Mar 1, 2006·Seminars in Interventional Radiology·Robert J Lewandowski, Riad Salem

❮ Previous
Next ❯

Citations

Mar 6, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Ryan T GroeschlT Clark Gamblin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.