Regional intestinal blood flow and nitric oxide synthase inhibition during sepsis in the rat

Annals of Surgery
K Klemm, F G Moody

Abstract

Regional circulatory changes in intestinal mucosa were evaluated after the onset of septic shock and the effect of nitric oxide (NO) inhibition on mucosal blood flow was investigated at different locations along the intestine. The response of intestinal blood flow to different physiologic and pharmacologic stimuli is known to vary along the intestine, but limited data are available on regional alterations in intestinal blood flow during septic shock. These regional variations in intestinal blood flow could become important because NO inhibition might restore the circulation of one segment of the gut or exacerbate ischemia that may be occurring concomitantly in another segment of the intestine. Mucosal blood flow was studied with fluorescent microspheres in conscious unrestrained rats before and 2, 4, and 6 hours after lipopolysaccharide (LPS, 20 mg/kg intraperitoneally) induced sepsis in the presence and absence of the nitric oxide synthase inhibitor N(G)-nitro-L-argininemethylester (L-NAME, 5 mg/kg subcutaneously). Control mucosal blood flow was significantly higher in the ileum than in the duodenum, jejunum, or colon. During LPS-induced sepsis, mucosal blood flow to the ileum decreased and perfusion to the remaining gut was p...Continue Reading

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Citations

Dec 18, 2001·Pharmacology & Therapeutics·F FeihlL Liaudet
Oct 15, 2003·Burns : Journal of the International Society for Burn Injuries·Andrew Rawlingson
Jan 11, 2000·Critical Care Medicine·B E Van Hoozen, T E Albertson
Jan 7, 2004·Critical Care Medicine·Mark M KnuepferAndrew J Lechner
Oct 16, 2004·Critical Care Medicine·Yvette C LuikingNicolaas E Deutz
Jun 4, 2008·Biological & Pharmaceutical Bulletin·Ryuji KatoKazuhiko Tanaka
Feb 5, 2015·Biochemistry Research International·Feng-Hua ChenGui-Ming Chen
Jul 20, 2002·Critical Care Medicine·Xavier VillaJohn F Thompson
Jul 11, 2008·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Dietmar TamandlPeter Goetzinger
Jul 12, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·M J MorinP A Gruppuso

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