Regional involvement of an endothelium-derived contractile factor in the vasoactive actions of neuropeptide Y in bovine isolated retinal arteries

British Journal of Pharmacology
D PrietoN Nyborg

Abstract

1. In vitro experiments in a microvascular myograph were designed in order to investigate the effects of human neuropeptide Y (NPY), its receptor subtype and the mechanisms underlying NPY actions in bovine isolated retinal proximal (PRA) and distal (DRA) arteries. 2. A single concentration of NPY (10 nM) induced a prompt and reproducible contraction which reached a plateau within 1-4 min, after which the response returned to baseline over the next 2-10 min. Cumulative addition of NPY induced concentration-dependent contractions of bovine retinal arteries, with an EC50[M] of 1.7 nM and a maximal response equal to 54 +/- 8% of Emax (absolute maximal contractile levels of vessels) and not different from that obtained by a single addition of the peptide. There were no significant differences in either sensitivity or maximal response to NPY between PRA and DRA. 3. Porcine NPY and the selective Y1-receptor agonist, [Pro34]NPY, also induced concentration-dependent contractions of the retinal arteries with a potency and maximal response not significantly different from those of human NPY; in contrast, the selective Y2-receptor agonist, NPY(13-36), caused only a 5% contraction at the highest concentration used. 4. Removal of extracellul...Continue Reading

References

Oct 1, 1991·Trends in Pharmacological Sciences·M C Michel
Jan 10, 1990·European Journal of Pharmacology·E Granstam, S F Nilsson
Oct 1, 1988·British Journal of Pharmacology·R Andriantsitohaina, J C Stoclet
Sep 13, 1989·European Journal of Pharmacology·M Klaas, R Wadsworth
Jan 1, 1989·International Ophthalmology·P J Nielsen, N C Nyborg
Dec 1, 1986·Circulation Research·R C KukrejaE F Ellis
Jul 1, 1993·Journal of Cardiovascular Pharmacology·W ErdbrüggerM C Michel
Jun 1, 1993·Pflügers Archiv : European journal of physiology·Z XiongD W Cheung
Jan 1, 1993·Annual Review of Pharmacology and Toxicology·C Wahlestedt, D J Reis

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Citations

Sep 11, 2007·British Journal of Pharmacology·S L Parker, A Balasubramaniam
Jul 18, 2006·European Journal of Pharmacology·Tatsuru TsurumakiHiroshi Higuchi
Jul 16, 2008·Journal of Hypertension·Nicola SantoroLaura Perrone
Nov 24, 2004·British Journal of Pharmacology·Dolores PrietoMedardo Hernández
Jan 10, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J YouR M Bryan
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·K AyajikiN Toda
Jul 16, 2005·Current Eye Research·J Michael SelbachElke Lütjen-Drecoll
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Angela BischoffMartin C Michel

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