PMID: 7021275Sep 1, 1981Paper

Regional localization of cerebral edema following fluid and insulin therapy in streptozotocin-diabetic rats

Diabetes
P A Tornheim

Abstract

To evaluate the location and early time course for development of cerebra edema following therapy for diabetes, streptozotocin-diabetic rats were subjected to constant i.v. infusion with saline and regular insulin. At the end of 1, 2, and 5 h of therapy, these rats were killed and tested for density of the cerebral cortex, subcortical white matter, caudate-putamen, thalamus, and medulla. Density data from treated animals were compared with those from control animals. From these data, change in brain tissue volume as water was calculated. Diabetic animals killed after 1 h of fluid and insulin therapy demonstrated a modest increase in brain water content of all areas tested except white matter. Following 2 h of therapy, all regions tested were edematous, with a magnitude of edema that was similar to that seen at 1 h. After 5 h of therapy, there was further increase in water content of the cerebral cortex, but not the other regions examined. Treatment with saline alone did not result in central overhydration. The findings of this study suggest that aggressive therapy with fluids and insulin, but not fluid alone, results in global overhydration of the brains of diabetic animals. Prolonged fluid and insulin treatment with a return o...Continue Reading

Citations

Oct 12, 2000·Diabetes/metabolism Research and Reviews·J A Edge
Dec 2, 1999·Pediatric Neurology·C P MahoneyM DelAguila
May 17, 2002·Journal of Diabetes and Its Complications·Irma FiordalisiM G F Gilliland
May 2, 1985·The New England Journal of Medicine·E J KraneJ I Wolfsdorf
May 16, 2002·Current Opinion in Pediatrics·Desmond Bohn, Denis Daneman
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