Abstract
To evaluate the location and early time course for development of cerebra edema following therapy for diabetes, streptozotocin-diabetic rats were subjected to constant i.v. infusion with saline and regular insulin. At the end of 1, 2, and 5 h of therapy, these rats were killed and tested for density of the cerebral cortex, subcortical white matter, caudate-putamen, thalamus, and medulla. Density data from treated animals were compared with those from control animals. From these data, change in brain tissue volume as water was calculated. Diabetic animals killed after 1 h of fluid and insulin therapy demonstrated a modest increase in brain water content of all areas tested except white matter. Following 2 h of therapy, all regions tested were edematous, with a magnitude of edema that was similar to that seen at 1 h. After 5 h of therapy, there was further increase in water content of the cerebral cortex, but not the other regions examined. Treatment with saline alone did not result in central overhydration. The findings of this study suggest that aggressive therapy with fluids and insulin, but not fluid alone, results in global overhydration of the brains of diabetic animals. Prolonged fluid and insulin treatment with a return o...Continue Reading
Citations
Oct 12, 2000·Diabetes/metabolism Research and Reviews·J A Edge
Jul 19, 2006·Diabetologia·J A EdgeD B Dunger
Dec 2, 1999·Pediatric Neurology·C P MahoneyM DelAguila
May 17, 2002·Journal of Diabetes and Its Complications·Irma FiordalisiM G F Gilliland
Mar 16, 2004·Pediatric Diabetes·A Muir
May 2, 1985·The New England Journal of Medicine·E J KraneJ I Wolfsdorf
May 16, 2002·Current Opinion in Pediatrics·Desmond Bohn, Denis Daneman
May 1, 2008·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Daniel L Levin
Jan 1, 1984·Acta Neuropathologica·R R ShiversR F Del Maestro
Sep 1, 1986·Indian Journal of Pediatrics·D G Patel, S C Kalhan
Jan 1, 1996·Life Sciences·G D HarrisC Yu
Aug 4, 2004·The Journal of Pediatrics·Lynne L Levitsky
Jul 4, 2006·Neurobiology of Disease·Cory TothDouglas W Zochodne
Dec 24, 2008·Brain Research·William H HoffmanAnuska V Andjelkovic
Apr 23, 2003·Hypertension·Anees Ahmad BandayMustafa F Lokhandwala
Jun 29, 2004·Diabetes Care·Andrew B MuirArlan L Rosenbloom
Nov 17, 2020·Pediatric Diabetes·Svetlana AzovaJoseph Wolfsdorf