Regional lung densities in alpha-1 antitrypsin deficiency compared to predicted values

Respiratory Research
Berend C StoelDavid G Parr

Abstract

We developed a method to calculate a standard score for lung tissue mass derived from CT scan images from a control group without respiratory disease. We applied the method to images from subjects with emphysema associated with alpha-1 antitrypsin deficiency (AATD) and used it to study regional patterns of differential tissue mass. We explored different covariates in 76 controls. Standardization was applied to facilitate comparability between different CT scanners and a standard Z-score (Standard Mass Score, SMS) was developed, representing lung tissue loss compared to normal lung mass. This normative data was defined for the entire lungs and for delineated apical, central and basal regions. The agreement with DLCO%pred was explored in a data set of 180 patients with emphysema who participated in a trial of alpha-1-antitrypsin augmentation treatment (RAPID). Large differences between emphysematous and normal tissue of more than 10 standard deviations were found. There was reasonable agreement between SMS and DLCO%pred for the global densitometry (κ = 0.252, p < 0.001), varying from κ = 0.138 to κ = 0.219 and 0.264 (p < 0.001), in the apical, central and basal region, respectively. SMS and DLCO%pred correlated consistently acros...Continue Reading

References

Jul 1, 1978·Journal of Computer Assisted Tomography·O H WegenerH Oeser
Aug 11, 1984·Lancet·M D HayhurstJ Best
Jul 1, 1996·American Journal of Respiratory and Critical Care Medicine·P A GevenoisJ C Yernault
Nov 1, 1996·AJR. American Journal of Roentgenology·P A GevenoisJ C Yernault
Apr 10, 1999·Investigative Radiology·B C StoelJ H Reiber
Apr 3, 2001·American Journal of Respiratory and Critical Care Medicine·L J DowsonR A Stockley
Dec 4, 2003·Thorax·P A DawkinsR A Stockley
Mar 3, 2004·Radiology·David G Parr, Robert A Stockley
Jul 24, 2004·American Journal of Respiratory and Critical Care Medicine·David G ParrRobert A Stockley
Aug 13, 2004·American Journal of Respiratory and Critical Care Medicine·David G ParrRobert A Stockley
Aug 25, 2004·Acta Radiologica·S B ShakerN H Holstein-Rathlou
Oct 16, 2004·Investigative Radiology·Berend C Stoel, Jan Stolk
Feb 20, 2007·Respiratory Medicine·Suzanne MarshRichard Beasley
Mar 3, 2007·The European Respiratory Journal·J StolkB C Stoel
Jul 24, 2007·Respiratory Medicine·Jan StolkBerend C Stoel
Dec 6, 2008·Proceedings of the American Thoracic Society·Berend C StoelJan Stolk
Dec 6, 2008·Proceedings of the American Thoracic Society·Berend C StoelJan Stolk
Mar 28, 2009·The European Respiratory Journal·T B GrydelandP S Bakke
Jun 23, 2011·American Journal of Respiratory and Critical Care Medicine·Jan Stolk, Berend C Stoel
Jul 25, 2012·AJR. American Journal of Roentgenology·Onno M MetsPim A de Jong
Feb 11, 2014·Medical Physics·M StaringB C Stoel
Mar 1, 1993·The European Respiratory Journal·P H QuanjerJ C Yernault
May 2, 2015·American Journal of Respiratory and Critical Care Medicine·Esther PompeFirdaus A A Mohamed Hoesein
Jul 2, 2015·American Journal of Respiratory and Critical Care Medicine·Jan StolkBerend C Stoel
May 28, 2016·The European Respiratory Journal·Deepak R SubramanianDavid G Parr
Feb 12, 2017·Chest·Peter J Barnes

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Software Mentioned

SPSS
Respreeza
ulmo
densitometry

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