Regional lymph node irradiation in locally advanced Merkel cell carcinoma reduces regional and distant relapse and improves disease-specific survival.

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Neal AndruskaMackenzie D Daly

Abstract

One-third of patients with Merkel cell carcinoma (MCC) present with locally advanced disease involving the regional lymph nodes, but indications for regional lymph node radiation therapy (rLN-RT) are not well established. 72 patients with locally advanced MCC were retrospectively reviewed. Regional lymph nodes were addressed with observation, lymph node dissection (LND) alone, definitive nodal radiotherapy (DnRT), or LND plus adjuvant nodal radiotherapy (AnRT). Cox regression was used to compare treatment modalities in terms of regional recurrence-free survival (RRFS), distant recurrence-free survival (DRFS), disease-free survival (DFS) and disease-specific survival (DSS). rLN-RT, including both DnRT and AnRT, improved RRFS (Hazard ratio (HR): 0.07, 95% confidence interval (CI): 0.01-0.40, p = 0.003), DRFS (HR: 0.28, CI: 0.11-0.76, p = 0.01), DFS (HR: 0.23, CI: 0.09-0.58, p = 0.002), and DSS (HR: 0.23, CI: 0.06-0.90, p = 0.03). AnRT improved DFS and DSS in high-risk subgroups (e.g., extranodal extension (ENE), ≥ 2 positive lymph nodes, or bulkier lymph nodes). The benefit of AnRT increased with higher disease burden. After controlling for these adverse factors, AnRT significantly improved RRFS (HR: 0.04, CI: 0.01-0.37, p = 0.00...Continue Reading

References

Jul 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J H LeonardG W Birrell
Feb 2, 2002·American Journal of Clinical Oncology·Hans Theodor EichRolf-Peter Müller
Jun 4, 2005·ANZ Journal of Surgery·Michael J VenessVal Gebski
Mar 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pablo MojicaJoshua D I Ellenhorn
Jul 14, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T JouaryUNKNOWN Groupe de Cancérologie Cutanée of the Société Française de Dermatologie
Feb 14, 2014·Journal of the American Academy of Dermatology·Jayasri G IyerPaul Nghiem
Nov 7, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jennifer S KoSteven D Billings
Jan 27, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A ServyM F Avril
Jun 3, 2016·Annals of Surgical Oncology·Tobin StromJimmy J Caudell
Jun 13, 2018·Journal of the National Comprehensive Cancer Network : JNCCN·Christopher K BichakjianAnita M Engh
Feb 1, 2020·Science·Suzanne L TopalianDrew M Pardoll
Apr 24, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Suzanne L TopalianPaul Nghiem

❮ Previous
Next ❯

Citations

Jul 23, 2021·Journal of the American Academy of Dermatology·Fan WangXian Jiang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.