Regional mapping of the human platelet-activating factor receptor gene (PTAFR) to 1p35-->p34.3 by fluorescence in situ hybridization

Cytogenetics and Cell Genetics
P B ChaseJ W Regan

Abstract

The human platelet-activating factor cell-surface receptor (PTAFR) is a G protein-coupled receptor thought to contribute to many atopic and inflammatory diseases and, perhaps, to the growth of some neoplasms. Exploring the possibility that the PTAFR might be involved in the genetic predisposition to any disease requires knowledge of its chromosomal localization. In this paper we have used a 20-kb human genomic fragment containing the coding sequence of the cloned PTAFR to determine the regional chromosomal localization of the gene. Using fluorescence in situ hybridization, the localization of the human PTAFR gene was mapped to 1p35-->p34.3.

Citations

Aug 31, 2000·Annual Review of Biochemistry·S M PrescottT M McIntyre
Jun 7, 2017·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Cong Zhang, Qian Sun
Jan 26, 2005·Journal of Medical Primatology·William E RoudebushHilton I Kort
Nov 16, 2002·Prostaglandins & Other Lipid Mediators·Satoshi IshiiTakao Shimizu

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