PMID: 9438437Jan 23, 1998Paper

Regional metabolite concentrations in human brain as determined by quantitative localized proton MRS

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
P J Pouwels, J Frahm

Abstract

The regional distribution of brain metabolites was studied in several cortical white and gray matter areas, cerebellum, and thalamus of young adults with use of quantitative single-voxel proton MRS at 2.0 T. Whereas the neuronal compound N-acetylaspartate is distributed homogeneously throughout the brain, N-acetylaspartylglutamate increases caudally and exhibits higher concentrations in white matter than in gray matter. Creatine, myo-inositol, glutamate, and glutamine are less concentrated in cortical white matter than in gray matter. The highest creatine levels are found in cerebellum, parallel to the distribution of creatine kinase and energy-requiring processes in the brain. Also myo-inositol has highest concentrations in the cerebellum. Choline-containing compounds exhibit a marked regional variability with again highest concentrations in cerebellum and lowest levels and a strong caudally decreasing gradient in gray matter. The present findings neither support a metabolic gender difference (except for a 1.3-fold higher myo-inositol level in parietal white matter of female subjects) nor a metabolic hemispheric asymmetry.

References

Apr 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·U Klose
Jan 1, 1989·Neuroscience and Biobehavioral Reviews·D L Birken, W H Oldendorf
Jul 1, 1989·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J FrahmR Sauter
Jan 1, 1985·Progress in Lipid Research·P S Sastry
Jun 1, 1980·Brain : a Journal of Neurology·A J RockelT P Powell
Aug 1, 1994·Neurochemical Research·P Morell, A H Ousley
Jan 1, 1993·Developmental Neuroscience·A BrandD Leibfritz
Aug 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P B BarkerJ H Anderson
Sep 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K L BeharO A Petroff
Sep 1, 1994·Journal of Computer Assisted Tomography·M J FulhamG Di Chiro
Dec 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S W Provencher
Apr 1, 1993·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J R MoffettJ H Neale
Mar 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B J SoherP B Barker
Jul 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J W PanH P Hetherington
Jul 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H P HetheringtonG M Pohost
Sep 5, 1996·Brain Research. Molecular Brain Research·S E IlyinC R Plata-Salamán
Jan 1, 1996·Developmental Neuroscience·D Holtzman
Nov 1, 1996·Journal of Magnetic Resonance. Series B·M Ala-KorpelaS R Williams

❮ Previous
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Citations

Feb 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C G Choi, J Frahm
May 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·N LundbomG Di Chiro
Jul 10, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P E SijensM M Breteler
Jan 22, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G HelmsH Link
Mar 22, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P B BarkerA Horská
Sep 7, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M A McLeanJ S Duncan
Mar 10, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·N SchuffM W Weiner
Aug 31, 2002·Journal of Magnetic Resonance Imaging : JMRI·Irina MaderWolfgang Grodd
Nov 2, 2002·Journal of Magnetic Resonance Imaging : JMRI·Mario MascalchiNatale Villari
Jul 10, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M A ThomasB Guze
Jul 31, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G Helms
Feb 4, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Oliver NattJens Frahm
Jun 19, 2001·NMR in Biomedicine·S W Provencher
Jun 19, 2001·NMR in Biomedicine·H in 't ZandtA Heerschap
Oct 29, 2009·Neuroradiology·Luaba TshibandaQuentin Noirhomme
Mar 9, 2004·Brain Research. Brain Research Reviews·Amy J Ross, Perminder S Sachdev
Jul 28, 2012·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·S MazzettiM Stasi
Dec 17, 2003·Biological Psychiatry·Jennifer G LevittJeffrey R Alger
Oct 2, 2001·Journal of Psychiatric Research·T MichaelisE Fuchs
Oct 25, 2003·International Journal of Radiation Oncology, Biology, Physics·Sandeep HunjanLei Xing
Apr 9, 1999·Magnetic Resonance Imaging·R A KomoroskiC N Karson
May 19, 2001·Neurologic Clinics·P M Ruggieri, I M Najm
Aug 30, 2000·Pediatric Neurology·B WilkenJ Frahm
Apr 14, 2010·Chemical Reviews·Kristine GlundeZaver M Bhujwalla
Feb 6, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sujung J YoonPerry F Renshaw
Jul 6, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alice EgertonJames M Stone
Jul 19, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nina V KraguljacAdrienne C Lahti
May 3, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lianne SchmaalAnna E Goudriaan
Nov 2, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Maartje M L de WinWim van den Brink
Apr 13, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mark A FryeM Albert Thomas

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