Regional myocardial blood flow redistribution as a cause of postprandial angina pectoris

Circulation
R R BaligaJ S Kooner

Abstract

Postprandial angina pectoris has been recognized for more than two centuries and can be identified in up to 10% of patients with chronic ischemic heart disease. Redistribution of myocardial blood flow, from a region supplied by a severely stenotic coronary artery to those supplied by less diseased or normal vessels, is a potential mechanism of postprandial angina. To test this hypothesis, we have determined the effects of a standard liquid meal on whole heart and regional myocardial blood flow, measured by means of dynamic positron emission tomography (PET) with 15O-labeled water in 14 patients with a reproducible history of postprandial angina and 7 matched control subjects. The standard liquid meal precipitated angina pectoris in all patients. Baseline whole heart blood flow was similar and increased normally after the meal in patients (0.97+/-0.14 to 1.14+/-0.25 mL.min(-1).g(-1), P<.04) as in control subjects (0.92+/-0.12 to 1.02+/-0.13 mL.min(-1).g(-1), P<.02). In contrast, the coefficient of variation of blood flow increased significantly after the standard liquid meal in patients (34+/-9%, P<.05 versus baseline) but not in control subjects (17+/-7%, P=NS versus baseline). In patients, analysis of regional myocardial blood...Continue Reading

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Citations

Aug 27, 2003·Metabolism: Clinical and Experimental·Thomas C Wascher, Ursula Boes
Jan 12, 2001·Journal of the American College of Cardiology·O O AkinboboyeS R Bergmann
Dec 12, 2002·Journal of the American College of Cardiology·Woo-Young ChungYun-Shik Choi
Sep 22, 2009·International Journal of Cardiology·Gabriele FragassoAlberto Margonato
Apr 17, 2007·The Journal of Pain : Official Journal of the American Pain Society·Chao QinRobert D Foreman
Sep 12, 2007·The American Journal of Cardiology·William B White

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