Regional myocardial perfusion in patients with atherosclerotic coronary artery disease, at rest and during angina pectoris induced by tachycardia

A MaseriM De Nes


We studied regional myocardial perfusion by scintigraphic computer-assisted analysis of initial distribution, washout rates, and residual activity of 133Xe injected into the left coronary artery of four patients with normal arteriograms and 14 patients with coronary stenosis. At rest, residual activity in poststenotic regions was always greater than in control regions, but initial washout rates were not slower. During angina, following xenon injections, the amount of indicator distributed to the poststenotic regions was markedly reduced; the increase of the initial washout rates was smaller than in control regions relative to rest, and residual activity was higher. Initial washout rates did not differ as much as from those of normal myocardium because in severe ischemia too little indicator is deposited initially in these regions to produce a change of any magnitude. Indeed, when angina was induced immediately after the xenon injection, poststenotic washout rates became much slower during angina than at rest, a finding that implicates functional factors in impairing poststenotic myocardial perfusion during angina.


Sep 1, 1979·Cardiovascular Radiology·P R Lichtlen, H J Engel
Apr 5, 1979·The New England Journal of Medicine·C E Welch, R A Malt
Oct 1, 1978·British Journal of Clinical Pharmacology·R H Swanton, D J Coltart
Feb 25, 1998·Pacing and Clinical Electrophysiology : PACE·E GiannitsisU Stierle
Jun 1, 1986·British Heart Journal·S C Webb, P A Poole-Wilson
Dec 18, 2010·Drugs·José Ignacio Abad RicoEduardo Rocha
Sep 29, 1999·International Journal of Cardiology·C KishimotoH Saji
Sep 13, 1980·Lancet
Jul 17, 1998·Journal of cardiology·T O Cheng
Aug 1, 1990·Naunyn-Schmiedeberg's Archives of Pharmacology·S J MacLennan, G R Martin
Jan 1, 1991·European Journal of Clinical Pharmacology·M DellborgK Swedberg
Feb 13, 2004·Progress in Cardiovascular Diseases·Srilakshmi Konidala, David D Gutterman
Jul 1, 1997·Progress in Cardiovascular Diseases·M Syed, M Lesch
Sep 1, 1988·Cardiovascular Drugs and Therapy·C W Hamm, W Bleifeld
Jan 1, 1983·Pharmacology & Therapeutics·A G Ellrodt, B N Singh
Sep 1, 1988·Progress in Cardiovascular Diseases·R F WilsonC W White
Nov 23, 1976·The American Journal of Cardiology·A Maseri
Apr 1, 1990·American Heart Journal·L SpinelliM Condorelli
Feb 1, 1982·Clinical Cardiology·S M CobbeP A Poole-Wilson
May 1, 1987·The American Journal of Cardiology·T SugiuraD H Spodick
Oct 15, 2011·The American Journal of Cardiology·Rajakrishnan VijayakrishnanD H Spodick
Jan 1, 1982·International Journal of Cardiology·W P SantamoreR A Carey
Dec 1, 1978·American Heart Journal·S Wessler, S N Gitel
Jun 1, 1982·Angiology·T WinsorJ R Bernett
Jan 1, 1981·Journal of Neurosurgery·S Wessler, S N Gitel
Feb 1, 1982·Circulation·Y KoiwayaM Nakamura
Jun 1, 1980·British Heart Journal·A Maseri
Apr 21, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Gianmario SambucetiA L'abbate
Feb 1, 1979·Postgraduate Medicine·S Wessler, S N Gitel
Mar 1, 1979·Hospital Practice·S P GlasserB S Maniscalco
Jul 1, 1987·Journal of General Internal Medicine·K Kroenke

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