Regional myocardial perfusion rates in patient with coronary artery disease

The Journal of Clinical Investigation
P J CannonE M Dwyer


Regional myocardial perfusion rates were estimated from the myocardial washout of (133)Xenon in 24 patients with heart disease whose coronary arteriograms were abnormal and 17 similar subjects whose coronary arteriograms were judged to be normal. Disappearance rates of (133)Xe from multiple areas of the heart were monitored externally with a multiple-crystal scintillation camera after the isotope had been injected into a coronary artery and local myocardial perfusion rates were calculated by the Kety formula. The mean myocardial perfusion rates in the left ventricle exceeded those in the right ventricle or atrial regions in subjects without demonstrable coronary artery disease. In this group there was a significant lack of homogeneity of local perfusion rates in left ventricular myocardium; the mean coefficient of variation of left ventricular local perfusion rates was 15.8%. In the patients with radiographically demonstrable coronary artery disease, a variety of myocardial perfusion patterns were observed. Local capillary blood flow rates were depressed throughout the myocardium of patients with diffuse coronary disease but were subnormal only in discrete myocardial regions of others with localized occlusive disease. Local myo...Continue Reading


Nov 1, 1967·The American Journal of Cardiology·T N James
Apr 1, 1972·The Journal of Clinical Investigation·P J CannonE M Dwyer
Sep 1, 1967·The Journal of Clinical Investigation·J M SullivanR Gorlin
Nov 1, 1962·The Journal of Clinical Investigation·N KRASNOWR GORLIN

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