Regional Neocortical Gray Matter Structure and Sleep Fragmentation in Older Adults

Sleep
Andrew S P LimDavid A Bennett

Abstract

To test the hypothesis that greater sleep fragmentation is associated with regionally decreased cortical gray matter volume in older community-dwelling adults without cognitive impairment. We studied 141 community-dwelling older adults (median age 82.9; 73% female) without cognitive impairment or stroke, and not using sedative/ hypnotic medications, participating in the Rush Memory and Aging Project. We quantified sleep fragmentation from 7 d of actigraphy using the metric kRA and related this to total cortical gray matter volume, and regional gray matter volume in 34 cortical regions quantified by automated segmentation of magnetic resonance imaging data. We determined statistical significance and accounted for multiple comparisons by empirically estimating the false discovery rate by permutation. Lower total cortical gray matter volume was associated with higher sleep fragmentation (coefficient +0.23, standard error [SE] 0.11, P = 0.037). Lower gray matter volumes in four cortical regions were accompanied by higher sleep fragmentation with a false discovery rate < 0.05: the left (coefficient +0.36, SE 0.10, P = 2.7 × 10(-4)) and right (coefficient +0.31, SE 0.10, P = 4.0 × 10(-3)) lateral orbitofrontal cortices, and the adjac...Continue Reading

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Citations

Jun 6, 2018·Journal of Alzheimer's Disease : JAD·David A BennettJulie A Schneider
Nov 6, 2018·Inflammatory Bowel Diseases·Taha QaziRobert Burakoff
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Oct 20, 2021·PLoS Computational Biology·Grégory HammadChristina Schmidt
Aug 2, 2021·The Journal of Nervous and Mental Disease·Hui ZhangQi Guo

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