PMID: 7546254Aug 1, 1995Paper

Regional skin blood flow in deep burn wounds: a preliminary report

Burns : Journal of the International Society for Burn Injuries
H J WangS Z Lin

Abstract

Local skin blood flow (LSBF) using the Walker's deep burn rat model was studied on the first three postburn days using the carbon-14 iodoantipyrine ([14C]IAP) perfusion method. The radioactive [14C]IAP (12.5 microCi) was infused through the femoral vein over a period of 30 seconds and the blood samples were collected by a free flow from the femoral artery at 5-s intervals to evaluate the concentration of the isotope, in the blood. At the conclusion of the infusion, the rats were guillotined and biopsies were obtained from the burned skin, unburned skin from burned rats and skin from sham control rats to assay the isotope in the skin. The LSBF was calculated from the skin tissue and plasma radioactivity data using Jay's equation. The results showed significant decreases of the skin blood flow in the deep burn wound with 4.05 +/- 1.16, 5.31 +/- 1.32 and 4.77 +/- 2.48 ml/100 g/min as compared to the LSBF of unburned skin 10.27 +/- 1.49, 12.39 +/- 2.05, 14.79 +/- 1.85 ml/100 g/min on postburn days 1, 2 and 3 (P < 0.05). The blood flow of the control group skin was 11.5 +/- 1.97 ml/100 g/min (P < 0.05). There were also significant differences of LSBF among burn wounds on postburn days 1, 2 and 3 (P < 0.05). Pathological study of the...Continue Reading

References

Jan 1, 1992·World Journal of Surgery·D HeimbachJ Marvin
Feb 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T M JayL Sokoloff
Jul 1, 1974·Annals of Surgery·B E Zawacki
Nov 1, 1968·The Journal of Trauma·H L Walker, A D Mason

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Citations

Mar 6, 2012·Immunologic Research·Biljana Draskovic-PavlovicMiodrag Colic
May 14, 1999·Burns : Journal of the International Society for Burn Injuries·J S KnablG Meissl
Feb 16, 2011·Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India·Bipin T VarghesePaul Sebastian
Nov 10, 2005·Burns : Journal of the International Society for Burn Injuries·A PappE Alhava
Aug 18, 2000·The Journal of Surgical Research·H BaskaranF Berthiaume

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