Abstract
To assess the effect of the duration of spontaneous hypoxic episodes and variations in haemodynamic parameters on cerebral and renal tissue oxygenation (rSo(2)C and rSo(2)R) in clinically stable preterm infants. Observational study. Neonatal intensive care unit of a university-affiliated children's hospital. Patients rSo(2)C and rSo(2)R and haemodynamic parameters were recorded for 2-3 h (once or twice) in clinically stable preterm neonates (n=10) using near-infrared spectroscopy, GE DASH 4000 and Bedmaster Software. rSo(2)C and rSo(2)R and fractional oxygen extraction (cerebral and renal fractional oxygen extraction: FOE-C and FOE-R, respectively) in association with the duration of pulse oximetry desaturation (pulse oximetry saturations (Sao(2)) < or =84%), bradycardia (heart rate < or =90 beats/min) and hypotension (mean blood pressure (MBP) <30 mm Hg). Among the 14 sets of recorded measurements, 128 hypoxic episodes with 5-10 (n=41), 15-20 (n=26), 25-30 (n=78), 35-40 (n=14), 45-50 (n=25) and > or =55 s (n=16) duration were identified. Prolongation of hypoxic episodes for more than 30 s was associated with major reductions in Sao(2), rSo(2)C and rSo(2)R without any significant changes in the regional FOE. Bradycardia occurre...Continue Reading
Citations
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