Regional tissue oxygenation in association with duration of hypoxaemia and haemodynamic variability in preterm neonates

Archives of Disease in Childhood. Fetal and Neonatal Edition
Anna Petrova, Rajeev Mehta

Abstract

To assess the effect of the duration of spontaneous hypoxic episodes and variations in haemodynamic parameters on cerebral and renal tissue oxygenation (rSo(2)C and rSo(2)R) in clinically stable preterm infants. Observational study. Neonatal intensive care unit of a university-affiliated children's hospital. Patients rSo(2)C and rSo(2)R and haemodynamic parameters were recorded for 2-3 h (once or twice) in clinically stable preterm neonates (n=10) using near-infrared spectroscopy, GE DASH 4000 and Bedmaster Software. rSo(2)C and rSo(2)R and fractional oxygen extraction (cerebral and renal fractional oxygen extraction: FOE-C and FOE-R, respectively) in association with the duration of pulse oximetry desaturation (pulse oximetry saturations (Sao(2)) < or =84%), bradycardia (heart rate < or =90 beats/min) and hypotension (mean blood pressure (MBP) <30 mm Hg). Among the 14 sets of recorded measurements, 128 hypoxic episodes with 5-10 (n=41), 15-20 (n=26), 25-30 (n=78), 35-40 (n=14), 45-50 (n=25) and > or =55 s (n=16) duration were identified. Prolongation of hypoxic episodes for more than 30 s was associated with major reductions in Sao(2), rSo(2)C and rSo(2)R without any significant changes in the regional FOE. Bradycardia occurre...Continue Reading

Citations

Feb 14, 2012·Cerebral Cortex·Pei-Yi LinMaria Angela Franceschini
Mar 5, 2013·Archives of Disease in Childhood. Fetal and Neonatal Edition·Manuel B SchmidHans Fuchs
Sep 19, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Corinna Binder-HeschlGerhard Pichler
May 29, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Katarzyna StarzecPrzemko Kwinta
Jan 9, 2017·The Journal of Pediatrics·Rosemary S C HorneFlora Y Wong
Nov 8, 2017·Journal of Pediatric Gastroenterology and Nutrition·Silvia MartiniLuigi Corvaglia
Jan 10, 2018·Frontiers in Pediatrics·Beri Massa-BuckKhodayar Rais-Bahrami
Aug 1, 2013·The Journal of Perinatal & Neonatal Nursing·Jacqueline M McGrath
Mar 19, 2019·Frontiers in Pediatrics·Meryl Vedrenne-CloquetXavier Durrmeyer
Jul 11, 2018·Children·Aisling A GarveyEugene M Dempsey

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