Regional transient osteoporosis of the foot and vitamin C deficiency

Clinical Rheumatology
Sandra RodriguezMichael P Phy

Abstract

We describe the clinical presentation and diagnostic tests of a patient with regional transient osteoporosis (RTO) of the foot. This patient presented with a 4-month history of left-foot pain, nonpitting edema, and brownish discolorations of both feet. He had a history of tobacco abuse, alcohol abuse, and malnutrition. Radiological studies revealed severe osteopenia in the feet, and a MRI revealed bone marrow edema. The bone biopsy was consistent with RTO. This patient also had vitamin C deficiency. This case suggests a link between vitamin C deficiency and RTO, a hypothesis supported by our review of relevant literature on osteoporosis and vitamin C.

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Citations

Nov 28, 2012·Archives of Gynecology and Obstetrics·Theodosia CharpidouChristoph Honegger
May 23, 2012·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Rajiv LimayeKamran Saeed
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Jun 5, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sridhar MuthusamiNarasimhan Srinivasan
Sep 3, 2016·Foot & Ankle International·Seyed Alireza MirghasemiShervin Rashidinia
Jul 8, 2011·Foot & Ankle International·Anna E SprinchornAndrew D Beischer
Jul 11, 2008·Internal Medicine Journal·E Patrozou, S Opal
Jan 17, 2021·Clinical Rheumatology·Scott A ElmanJoseph F Merola

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