Regional variation in human retinal vessel oxygen saturation

Experimental Eye Research
Ayda M ShahidiChris Hudson


The purpose of this study was to investigate regional differences in oxygen saturation of blood in first degree retinal vessels using a novel non-flash hyperspectral retinal camera (Photon etc Inc). Nine healthy individuals (mean age 24.4 ± 3.6 yrs, 5 males) were imaged at 548, 569, 586, 600, 605 and 610 nm wavelengths. Optical density values were extracted with the aid of Image-J software for blood oxygen saturation (SO2) determination. Arteriolar and venular SO2 were measured at three locations (ranging 1-3 optic nerve head radii) from the disc margin along the vessels in the superior and inferior temporal quadrants. Retinal SO2 was significantly higher in the superior temporal arteriole and venule as compared to the inferior temporal vessels (p = 0.033 and p = 0.032 for arterioles and venules, respectively). SO2 was not significantly different between the three measurement sites for any of the given vessels imaged (p > 0.05). In conclusion, greater SO2 values were found in the superior temporal first degree retinal arterioles and venules in young healthy individuals than in the equivalent inferior vessels. However, there were no detectable differences in retinal SO2 along each of the major vessels, a finding that is consiste...Continue Reading


Feb 1, 1992·The Journal of General Physiology·Robert A Linsenmeier, R D Braun
May 1, 1989·Ophthalmology·J B JonasG O Naumann
Apr 1, 1996·Ophthalmology·M T Nicolela, S M Drance
Apr 10, 2002·Circulation·Hirosuke Kobayashi, Naosada Takizawa
Jul 31, 2003·American Journal of Ophthalmology·Emma J Roff HiltonAndrew J Morgan
Nov 24, 2005·Investigative Ophthalmology & Visual Science·Dao-Yi YuEr-Ning Su
May 18, 2006·Acta Ophthalmologica Scandinavica·Georg Michelson, Mateusz Scibor
Feb 28, 2007·Investigative Ophthalmology & Visual Science·Shufan Wang, Robert A Linsenmeier
Mar 17, 2007·Current Eye Research·James M BeachBahram Khoobehi
Jun 15, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Gülnur BirolRobert A Linsenmeier
Nov 22, 2008·Journal of Biomedical Optics·Martin HammerDietrich Schweitzer
May 1, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Martin HammerJ Strobel
Mar 11, 2011·Eye·D J MordantA I McNaught
Nov 15, 2011·The British Journal of Ophthalmology·Sveinn Hakon Hardarson, Einar Stefánsson
Mar 8, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Rebekka Heitmar, Saima Safeen
Jul 13, 2012·Investigative Ophthalmology & Visual Science·Asbjorg GeirsdottirEinar Stefánsson


Apr 10, 2016·Experimental Eye Research·Michèle DesjardinsFrédéric Lesage
Jul 21, 2016·PloS One·Yuki NakanoAkitaka Tsujikawa
Nov 4, 2017·Acta Ophthalmologica·Rebekka HeitmarRobert P Cubbidge
Jun 10, 2014·Physiological Measurement·John Allen, Kevin Howell
Dec 20, 2019·International Ophthalmology Clinics·Edith R ReshefDemetrios G Vavvas
Sep 4, 2020·Translational Vision Science & Technology·Sophie LemmensIngeborg Stalmans
Jul 1, 2017·Biomedical Optics Express·Siyu ChenHao F Zhang
Jan 9, 2021·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Xiaodan SuiYanhui Ding
Jan 1, 2021·Photodiagnosis and Photodynamic Therapy·Aziz Ul Rehman, Shahzad Ahmad Qureshi
May 19, 2021·Translational Vision Science & Technology·Anupam K GargDaniel L Chao

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Related Papers

Investigative Ophthalmology & Visual Science
Kristine E LeeStacy M Meuer
IEEE Transactions on Bio-medical Engineering
Dietrich SchweitzerJ Strobel
International Journal of Microcirculation, Clinical and Experimental
H Hashimoto, R L Prewitt
© 2021 Meta ULC. All rights reserved