Regional variation in Langerhans cell distribution and density in normal human oral mucosa determined using monoclonal antibodies against CD1, HLADR, HLADQ and HLADP.

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
A T CruchleyC A Squier

Abstract

The distribution, density and activation of Langerhans cells (LC) has been established in biopsies of normal human buccal mucosa, hard palate, lateral border and dorsum of tongue, floor of mouth and lip taken from sudden death post mortems. LC were identified in cryostat sections with monoclonal antibodies against CD1, HLADR, HLADQ and HLADP using an immunoalkaline phosphatase technique. The use of post mortem material was validated by comparison with biopsies taken from volunteers. LC were predominantly situated in the basal and immediately suprabasal layers of the epithelium. In floor of mouth, lip, lateral border and dorsum of tongue the cells were found along the length of the epithelium. In buccal mucosa, although LC showed fundamentally a similar distribution, a tendency to cluster around the connective tissue papillae was also noted. In hard palate LC were found parallel to the surface in the mid zone of the epithelium. No evidence of LC free areas was found. Dorsum of tongue had the highest density of LC per mm epithelial surface length (28.3 cells per mm) which was significantly greater (P less than 0.05) than buccal mucosa (25.2) which in turn had significantly more cells (P less than 0.05) than lip (22.4). The lowest...Continue Reading

References

Jul 21, 1977·Nature·L KlareskogP A Peterson
Jul 21, 1977·Nature·G StinglK Wolff
Mar 1, 1986·Journal of Leukocyte Biology·K L Choi, D N Sauder
May 1, 1989·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·P M Farthing, A T Cruchley
Jan 1, 1989·Archives of Oral Biology·C A Francis, P M Farthing
Nov 1, 1986·Journal of Periodontal Research·G M Newcomb, R N Powell
Jan 1, 1988·Journal of Oral Pathology·L J WalshR N Powell
Sep 1, 1987·Journal of Clinical Pathology·W F Bodmer
Mar 1, 1986·Clinical and Experimental Dermatology·J AshworthR Mackie
Dec 1, 1986·The Journal of Investigative Dermatology·R D SontheimerG Nũnez
Jan 1, 1985·Immunogenetics·C NavarreteH Festenstein
Jan 1, 1966·Journal of Periodontal Research·H E Schroeder, J Theilade
Jan 1, 1984·The Journal of Investigative Dermatology·T E Daniels
Dec 1, 1984·Immunobiology·J W Streilein, P R Bergstresser
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·E FithianR Edelson
Jan 1, 1980·Scandinavian Journal of Immunology·L R Braathen, E Thorsby

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Citations

Jan 1, 1997·Archives of Oral Biology·A W Barrett, A M Raja
Dec 11, 1999·Clinics in Dermatology·T M LottiE Tsoureli
May 3, 2002·Clinical and Experimental Immunology·A HasanT Lehner
Sep 1, 1994·Journal of Clinical Periodontology·I P NunesT Kristoffersen
Feb 1, 1991·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A W BarrettJ Scott
Jan 1, 1992·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·L J WalshC G Cumming
Nov 1, 1994·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A W Barrett, C Scully
Aug 1, 1995·European Journal of Oral Sciences·D C SøhoelR Nilsen
Oct 19, 2004·Clinical Microbiology Reviews·Louis de RepentignyPaul Jolicoeur
Aug 28, 2012·Journal of Oral and Maxillofacial Pathology : JOMFP·Nutan TyagiAadithya B Urs
Feb 28, 2014·Journal of Oral and Maxillofacial Pathology : JOMFP·Taye J LasisiEffiong E Akang
Nov 20, 2013·North American Journal of Medical Sciences·Juhi UpadhyayRhitu Shekhar
Apr 9, 2008·Trends in Molecular Medicine·Natalija NovakJean-Pierre Allam
Sep 3, 2010·Anatomia, histologia, embryologia·B ArziF J M Verstraete
Jun 4, 2014·Reviews in Medical Virology·Laura Hertel
Nov 23, 2006·Archives of Oral Biology·Agnès BodineauSylvie Séguier
Jun 5, 2002·Journal of Endodontics·Adriano PiattelliMassimiliano Fioroni
Apr 26, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M Torres LimaS Durham
Jan 1, 1996·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·A W BarrettD M Williams
Nov 27, 2008·International Journal of Surgical Pathology·Evangelia PiperiStefan Pambuccian
Apr 1, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·B E McCartan, P J Lamey
Feb 1, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M F HaqueP M Speight
Feb 1, 1990·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·P M FarthingA T Cruchley
Mar 1, 1992·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·T E DanielsV L Ernster
Feb 1, 1995·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·W F van HeerdenR le Roux
May 1, 1993·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·T LombardiE Budtz-Jörgensen
Feb 1, 1994·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A T CruchleyC A Squier
Feb 1, 1995·Journal of Oral Rehabilitation·F MowlanaD Auger
Sep 1, 1993·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·J OhnoN Utsumi
Jul 1, 1991·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·S B Fox
Apr 1, 1993·Clinical and Experimental Immunology·A W BarrettJ A Goodacre
Mar 1, 1992·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A W BarrettJ Scott

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