Regional variation in the mechanical properties and fibre-type composition of the rat extensor digitorum longus muscle

Experimental Physiology
Roger W P KissaneG N Askew

Abstract

What is the central question of this study? Mammalian muscle is typically heterogeneous in fibre-type distribution, with distinct regional variation in composition. The effects this might have on mechanical performance are largely unknown. What is the main finding and its importance? Contractile properties vary regionally within a heterogeneous muscle. The mixed extensor digitorum longus muscle has phenotypically distinct compartments that differ in their isometric twitch kinetics, the optimal cycle frequency for maximal power generation and fatigue resistance. The mechanisms underpinning the decline in performance during fatigue differ between compartments. Regional variation in mechanical performance suggests that regions of the extensor digitorum longus muscle might be differentially recruited during locomotion, depending upon functional demand. Fibre-type composition is heterogeneous, and distribution varies spatially in many muscles, indicating that there might be regional variation in recruitment and mechanical output. The rat extensor digitorum longus muscle is composed of predominantly fast-twitch fibres and exhibits a gradient in phenotype, resulting in oxidative medial (areal composition 24.3% type I/IIa) and glycolyt...Continue Reading

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Citations

Nov 11, 2018·Muscle & Nerve·Roger W P KissaneStuart Egginton
Dec 7, 2018·Journal of Applied Physiology·Abdullah A Al-ShammariStuart Egginton
Dec 22, 2020·The Journal of Physiology·Ever Espino-GonzalezT Scott Bowen
Jan 15, 2021·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Roger W P KissaneStuart Egginton
Nov 12, 2021·Journal of Anatomy·Roger W P KissaneStuart Egginton

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