Regional variations in percutaneous absorption of methimazole: an in vitro study on cat skin

Journal of Veterinary Pharmacology and Therapeutics
K E HillPaul C Mills

Abstract

The use of transdermal gel medications in cats has become popular in veterinary medicine due to the ease of administration compared to oral medication. The research to support systemic absorption of drugs after transdermal gel administration and the preferred skin region to apply these drugs in cats is limited. The aim of this study was to characterize the effect of different skin regions on the percutaneous absorption pharmacokinetics of a commercially available transdermal methimazole after a finite dose was applied to feline skin in vitro. A commercial formulation of methimazole (10 mg) was applied to four skin regions (the inner stratum corneum of the ear, groin, neck, and thorax regions) from six cats. The receptor medium was sampled up to 36 h postapplication, and methimazole concentrations were measured using high-performance liquid chromatography. Methimazole was absorbed more completely across the pinnal skin, compared to the groin, neck, and thorax (P < 0.001), which justifies application to the pinna to maximize efficacy and also to minimize the effects of grooming.

References

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Feb 17, 2015·Journal of Veterinary Pharmacology and Therapeutics·K E HillJ P Chambers
Mar 3, 2015·Journal of Veterinary Pharmacology and Therapeutics·K E HillP C Mills

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Citations

Sep 11, 2016·Journal of Feline Medicine and Surgery·Kellyi K BensonJessica M Quimby
Jul 14, 2018·Journal of Veterinary Pharmacology and Therapeutics·William BuhlesValentine S Williams
Mar 3, 2015·Journal of Veterinary Pharmacology and Therapeutics·K E HillP C Mills
Jun 5, 2019·Journal of Feline Medicine and Surgery·Jessica M QuimbyDaniel L Gustafson

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