Regional variations in the progression of bone loss in two different mouse osteopenia models

Calcified Tissue International
Y KobayashiH Moriya

Abstract

Differences in trabecular and cortical bone loss have been demonstrated clinically, but differences in bone loss at different skeletal sites remain unclear. We examined regional variations in bone loss histomorphometrically in two strains of mice in which osteopenia progresses spontaneously: tiptoe-walking Yoshimura (twy) mice (from 4 to 37 weeks of age) and senescent ICR mice (from 4 to 88 weeks of age). Morphometrical measurements were obtained to investigate the changes with age in trabecular bone area and anterior cortical bone width in the lumbar vertebral body, trabecular bone area in the tibia, bone area in the parietal bone, and the cortical index in the humerus. Results showed that, in twy mice, trabecular turnover was higher than in ICR mice, and bone loss progressed in the following order: tibial trabecular bone, lumbar trabecular bone, parietal bone, lumbar anterior cortical bone, and the humerus. In ICR mice, bone formation declined after 60 weeks. Bone loss progressed in tibial trabecular bone and the parietal bone at 60 weeks of age, followed by lumbar trabecular bone, lumbar anterior cortical bone, and the humerus at 88 weeks of age. Bone loss varied at each site and between the two mouse strains, with different...Continue Reading

Citations

Sep 19, 2003·Bone·Virginia L FergusonSteven J Simske
Jun 3, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K JohnsonR Terkeltaub
Apr 26, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H BenesR J Shmookler Reis
Jun 11, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bernard P HalloranSharmila Majumdar
Dec 17, 2011·Revista española de geriatría y gerontología·Sergio Portal-NúñezPedro Esbrit
Aug 10, 2006·American Journal of Physical Anthropology·Joshua J Peck, Sam D Stout
May 26, 2009·Biochimica Et Biophysica Acta·Vincent EvertsMiep H Helfrich
Oct 3, 2003·The Journal of Biological Chemistry·Gethin ThomasChristian Lanctôt
Dec 6, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ralf OheimDemetrios T Braddock
Sep 25, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Shigeto HiratsukaNorimasa Iwasaki
Jan 20, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Carlos R FerreiraDemetrios T Braddock

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