Regional variations of contractile activity in isolated rat lymphatics

Microcirculation : the Official Journal of the Microcirculatory Society, Inc
Anatoliy A GashevDavid C Zawieja

Abstract

To evaluate lymphatic contractile activity in different regions of the lymphatic system in a single animal model (the rat thoracic duct, mesenteric, cervical, and femoral lymphatics) in response to changes in lymph pressure and flow. The systolic and diastolic diameters of isolated, cannulated, and pressurized lymphatic vessels were measured. Contraction frequency, ejection fraction, and fractional pump flow were determined. The influences of incrementally increased transmural pressure (from 1 to 9 cm H2O) and imposed flow (from 1 to 5 cm H2O transaxial pressure gradient) were investigated. The authors determined regional differences in lymphatic contractility in response to pressure and imposed flow. They found the highest pumping (at the optimal pressure levels) in mesenteric lymphatics and lowest pumping in thoracic duct. All lymphatics had their optimal pumping conditions at low levels of transmural pressure. Different degrees of the flow-induced inhibition of the pump were observed in the different types of lymphatics. During high flow, the active lymph pumps in thoracic duct and cervical lymphatics were almost completely abolished, whereas mesenteric and femoral lymphatics still exhibited significant active pumping. The a...Continue Reading

Citations

Apr 9, 2014·PloS One·Kristine H KurtzJerome W Breslin
Jun 27, 2013·Biomechanics and Modeling in Mechanobiology·C D BertramJ E Moore
Sep 23, 2014·Vascular Cell·Maria Giovanna ScioliAugusto Orlandi
Aug 12, 2014·Microvascular Research·Jerome W Breslin
Sep 25, 2014·The Journal of Surgical Research·Muholan KanapathyAlexander M Seifalian
Dec 12, 2012·Journal of Biomedical Optics·Timothy KassisJ Brandon Dixon
Dec 8, 2006·Annals of Biomedical Engineering·J Brandon DixonGerard L Coté
Jun 10, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Michael J DavisAnatoliy A Gashev
Nov 26, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Michael J DavisAnatoliy A Gashev
Nov 26, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Arun M VenugopalRandolph H Stewart
Jun 16, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Wei WangMariappan Muthuchamy
Jun 19, 2009·Lymphatic Research and Biology·David C Zawieja
Apr 5, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Michael J DavisJames E Moore
Aug 30, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Tony J AklAnatoliy A Gashev
Mar 16, 2012·Lymphatic Research and Biology·Anatoliy A GashevMichael J Davis
Mar 30, 2006·Lymphatic Research and Biology·Michael J DavisAnatoliy A Gashev
Oct 16, 2007·Lymphatic Research and Biology·Anatoliy A GashevDavid C Zawieja
Mar 26, 2008·Lymphatic Research and Biology·Lianne B DolanDonald C McKenzie
Jun 30, 2010·Lymphatic Research and Biology·Anatoliy A GashevEric A Bridenbaugh
Dec 18, 2012·Lymphatic Research and Biology·F MigniniC Cavallotti
Mar 28, 2013·Lymphatic Research and Biology·Anatoliy A Gashev, Victor Chatterjee
Sep 21, 2013·Lymphatic Research and Biology·Eric A BridenbaughDavid C Zawieja
Nov 13, 2008·The Journal of Physiology·Michael J DavisAnatoliy A Gashev
Dec 17, 2011·The Journal of Physiology·Daniela Negrini
Jul 1, 2006·The Journal of Physiology·Olga Yu GashevaAnatoliy A Gashev
Jul 11, 2006·The Journal of Physiology·Daniela Negrini
Jun 15, 2010·Trends in Endocrinology and Metabolism : TEM·J Brandon Dixon
Mar 17, 2010·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Anatoliy A Gashev, David C Zawieja
Dec 20, 2015·Lymphatic Research and Biology·Mohammad JafarnejadJ E Moore
Jun 4, 2008·Annals of the New York Academy of Sciences·Anatoliy A Gashev
Jun 4, 2008·Annals of the New York Academy of Sciences·Mariappan Muthuchamy, David Zawieja
Dec 15, 2012·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Sanjukta ChakrabortyMariappan Muthuchamy
Apr 7, 2011·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Takashi NagaiAnatoliy A Gashev
Oct 27, 2010·Annals of the New York Academy of Sciences·Anatoliy A Gashev
Oct 27, 2010·Annals of the New York Academy of Sciences·Sanjukta ChakrabortyMariappan Muthuchamy
Oct 27, 2010·Annals of the New York Academy of Sciences·J Brandon Dixon
Jan 9, 2014·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Elaheh RahbarDavid C Zawieja
Apr 23, 2014·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Irina Tsoy NizamutdinovaAnatoliy A Gashev
Jun 28, 2012·Journal of Biomedical Optics·Michael WeilerJ Brandon Dixon

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