Regional Ventilation and Aerosol Deposition with Helium-Oxygen in Bronchoconstricted Asthmatic Lungs

Journal of Aerosol Medicine and Pulmonary Drug Delivery
Elliot Eliyahu GreenblattJosé G Venegas

Abstract

Theoretical models suggest that He-O2 as carrier gas may lead to more homogeneous ventilation and aerosol deposition than air. However, these effects have not been clinically consistent and it is unclear why subjects may or may not respond to the therapy. Here we present 3D-imaging data of aerosol deposition and ventilation distributions from subjects with asthma inhaling He-O2 as carrier gas. The data are compared with those that we previously obtained from a similar group of subjects inhaling air. Subjects with mild-to-moderate asthma were bronchoconstricted with methacholine and imaged with PET-CT while inhaling aerosol carried with He-O2. Mean-normalized-values of lobar specific ventilation sV* and deposition sD* were derived and the factors affecting the distribution of sD* were evaluated along with the effects of breathing frequency (f) and regional expansion (FVOL). Lobar distributions of sD* and sV* with He-O2 were not statistically different from those previously measured with air. However, with He-O2 there was a larger number of lobes having sV* and sD* closer to unity and, in those subjects with uneven deposition distributions, the correlation of sD* with sV* was on average higher (p < 0.05) in He-O2 (0.84 ± 0.8) com...Continue Reading

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Citations

Mar 10, 2017·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Rui Carlos SáChantal Darquenne
Nov 23, 2016·The Journal of Allergy and Clinical Immunology·Emily M DeBoerAlan S Brody
Nov 23, 2018·Expert Opinion on Drug Delivery·P Worth LongestMichael Hindle
Feb 1, 2019·Journal of Engineering and Science in Medical Diagnostics and Therapy·Tilo Winkler
Nov 17, 2016·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Michael Y Yang, Hak-Kim Chan
Apr 20, 2018·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Luciana AlcoforadoJose G Venegas
Mar 12, 2021·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Tim Corcoran

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