Regional volumetric coronary blood flow measurement by digital angiography: in vivo validation

Academic Radiology
Sabee MolloiGhassan S Kassab

Abstract

There are well-known limitations to the use of visual estimation to assess the severity of coronary artery disease and luminal stenosis. This is especially true in the case of an intermediate coronary lesion (30%-70% diameter stenosis), where coronary arteriography is very limited in distinguishing ischemia-producing intermediate coronary lesions from non-ischemia-producing ones. For this reason, a functional measure of stenosis severity is desirable. The goal of this study is to validate a video densitometry technique for quantitative assessment of regional volumetric coronary blood flow. Coronary arteriography was performed in eight swine (body weight, 25-50 kg) after power injection of contrast material into the left main coronary artery. Phase-matched subtracted images were used to quantify regional coronary blood flow using a video densitometry technique. The in vivo regional flow measurements were validated using a transit time ultrasound flow probe. In 44 measurements, the ultrasound (Q(US)) and video densitometry (Q(VD)) regional flow measurements were related by Q(VD) = 0.98 Q(US) + 0.11 mL/min (r = 0.98). The results of mean regional coronary blood flow measurements for repeated coronary arteriograms of the first (Q(V...Continue Reading

References

Jan 1, 1990·International Journal of Cardiac Imaging·H MarinusA van Benthem
Mar 1, 1989·Medical Physics·S Y Molloi, C A Mistretta
Feb 1, 1987·Circulation·J T CusmaC A Mistretta
May 1, 1970·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·W RutishauserB Preter
Jan 1, 1983·Cardiovascular and Interventional Radiology·J H Bürsch
Jan 1, 2000·Physics in Medicine and Biology·Y ZhouS Molloi
Jan 1, 1995·IEEE Transactions on Medical Imaging·A ErsahinY J Qian

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Citations

Jan 8, 2011·The International Journal of Cardiovascular Imaging·Sabee MolloiJerry T Wong
Jan 8, 2011·The International Journal of Cardiovascular Imaging·Jerry T WongSabee Molloi
Nov 25, 2011·Journal of the Royal Society, Interface·Yunlong HuoGhassan S Kassab
Nov 19, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Ghada Kalsho, Ghassan S Kassab
Oct 7, 2008·The International Journal of Cardiovascular Imaging·Tamás UngiAttila Nemes
Jan 19, 2010·American Journal of Physiology. Heart and Circulatory Physiology·J YangR M Henkelman
Dec 14, 2016·Circulation. Cardiovascular Imaging·Logan HubbardSabee Molloi
Dec 6, 2018·Journal of Biomechanical Engineering·Mehran MirramezaniShawn C Shadden

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