Regionalised signalling within the extraembryonic ectoderm regulates anterior visceral endoderm positioning in the mouse embryo

Mechanisms of Development
Lucy RichardsonMagdalena Zernicka-Goetz

Abstract

The development of the anterior-posterior (AP) axis in the mammalian embryo is controlled by interactions between embryonic and extraembryonic tissues. It is well established that one of these extraembryonic tissues, the anterior visceral endoderm (AVE), can repress posterior cell fate and that signalling from the other, the extraembryonic ectoderm (ExE), is required for posterior patterning. Here, we show that signals from the prospective posterior ExE repress AVE gene expression and affect the distribution of the AVE cells. Surgical ablation of the prospective posterior, but not the anterior, extraembryonic region at 5.5 days of development (E5.5) perturbs the characteristic distal-to-anterior distribution of AVE cells and leads to a dramatic expansion of the AVE domain. Time-lapse imaging studies show that this increase is due to the ectopic expression of an AVE marker, which results in a symmetrical positioning of the AVE. Surgical ablation of this same ExE region after the distal-to-anterior migration has already commenced, at E5.75, does not affect the localisation of the AVE, indicating that this effect takes place within a short time window. Conversely, transplanting the prospective posterior, but not the anterior, extr...Continue Reading

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Citations

Feb 16, 2012·Nature Communications·Samantha A MorrisMagdalena Zernicka-Goetz
Jul 29, 2008·Development, Growth & Differentiation·Miguel L SoaresMagdalena Zernicka-Goetz
Dec 22, 2007·BMC Developmental Biology·Susana M Chuva de Sousa LopesM Azim Surani
Aug 21, 2007·BMC Developmental Biology·Aitana Perea-GomezMagdalena Zernicka-Goetz
Feb 23, 2012·Development·Claudio D Stern, Karen M Downs
Sep 26, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Michio YoshidaShinichi Aizawa
Jun 18, 2010·Current Opinion in Genetics & Development·Alexander W Bruce, Magdalena Zernicka-Goetz
Nov 26, 2015·Biochemical and Biophysical Research Communications·Katerina Drakou, Pantelis Georgiades
Jun 24, 2006·Current Opinion in Genetics & Development·Patrick P L TamSatomi S Tanaka
Jul 25, 2007·Current Opinion in Genetics & Development·Katsuyoshi TakaokaHiroshi Hamada
Oct 5, 2016·Mechanisms of Development·Isao Matsuo, Ryuji Hiramatsu
Sep 27, 2016·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Michio YoshidaShinichi Aizawa
Jan 27, 2017·Open Biology·Samantha A Morris
Jul 28, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Mary E Dickinson
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Sep 26, 2007·Journal of Cellular Physiology·Jaime A Rivera-Perez
Jun 19, 2009·Nature Reviews. Genetics·Magdalena Zernicka-GoetzAlexander W Bruce
Dec 31, 2020·Developmental Cell·Gianluca AmadeiMagdalena Zernicka-Goetz
Sep 10, 2010·Development·Luis C Fernandez-DiazFrancesco Blasi
Aug 5, 2006·Development·Claire Chazaud, Janet Rossant

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