Regionally selective atrophy after traumatic axonal injury.

Archives of Neurology
Matthew A WarnerRamon Diaz-Arrastia

Abstract

To determine the spatial distribution of cortical and subcortical volume loss in patients with diffuse traumatic axonal injury and to assess the relationship between regional atrophy and functional outcome. Prospective imaging study. Longitudinal changes in global and regional brain volumes were assessed using high-resolution magnetic resonance imaging-based morphometric analysis. Inpatient traumatic brain injury unit. Twenty-five patients with diffuse traumatic axonal injury and 22 age- and sex-matched controls. Changes in global and regional brain volumes between initial and follow-up magnetic resonance imaging were used to assess the spatial distribution of posttraumatic volume loss. The Glasgow Outcome Scale-Extended score was the primary measure of functional outcome. Patients underwent substantial global atrophy with mean whole-brain parenchymal volume loss of 4.5% (95% confidence interval, 2.7%-6.3%). Decreases in volume (at a false discovery rate of 0.05) were seen in several brain regions including the amygdala, hippocampus, thalamus, corpus callosum, putamen, precuneus, postcentral gyrus, paracentral lobule, and parietal and frontal cortices, while other regions such as the caudate and inferior temporal cortex were re...Continue Reading

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Citations

Feb 12, 2014·Nature Reviews. Neurology·David J SharpRobert Leech
Aug 8, 2013·Neuropsychology Review·Annabelle ArnouldMartial Van der Linden
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