PMID: 8942451Dec 1, 1996Paper

Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging

The American Journal of Psychiatry
A BertolinoD R Weinberger

Abstract

Several single-voxel proton magnetic resonance spectroscopy (1H-MRS) studies of patients with schizophrenia have found evidence of reductions of N-acetyl-aspartate (NAA) concentrations in the temporal lobes. Multislice proton magnetic resonance spectroscopy imaging (1H-MRSI) permits simultaneous acquisition and mapping of NAA, choline-containing compounds (CHO), and creatine/phosphocreatine (CRE) signal intensities from multiple whole brain slices consisting of 1.4-ml single-volume elements. We have used 1H-MRSI to assess the regional specificity of previously reported changes of metabolite signal intensities in schizophrenia. Hippocampal volume was also measured to test the relationship between 1H-MRSI findings and tissue volume in this region. Ratios of areas under the metabolite peaks of the proton spectra were determined (i.e., NAA/CRE, NAA/CHO, CHO/CRE) for multiple cortical and subcortical regions in 10 inpatients with schizophrenia. Patients showed significant reductions of NAA/CRE and NAA/CHO bilaterally in the hippocampal region and in the dorsolateral prefrontal cortex. There were no significant changes in CHO/CRE or in NAA ratios in any other area sampled. No significant correlation was found between metabolite ratio...Continue Reading

Citations

Jul 13, 1999·European Journal of Radiology·A Bertolino, D R Weinberger
Dec 21, 2000·Current Psychiatry Reports·P W Wang, T A Ketter
May 10, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·M X HuangJ M Canive
Aug 25, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·K OharaK Ohara
Feb 22, 2003·Journal of the American Academy of Child and Adolescent Psychiatry·Ronald A YeoWilliam M Brooks
Feb 7, 1998·Current Opinion in Neurobiology·M F Egan, D R Weinberger
Nov 28, 1997·Schizophrenia Research·R F DeickenM W Weiner
Jul 14, 1999·Schizophrenia Research·R F DeickenD Amend
Dec 25, 2003·Schizophrenia Research·Juan BustilloC Fernando Valenzuela
Oct 8, 2004·Schizophrenia Research·Sarah M Clinton, James H Meador-Woodruff
Mar 9, 2004·Brain Research. Brain Research Reviews·Amy J Ross, Perminder S Sachdev
Feb 24, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Giuseppe Blasi, Alessandro Bertolino
Mar 31, 2004·NeuroImage·Katherine L NarrRobert M Bilder
Nov 21, 2012·Child and Adolescent Psychiatric Clinics of North America·Xenia Protopopescu, Andrew J Gerber
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Jun 24, 2010·Biological Psychiatry·Meredith A ReidAdrienne C Lahti
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May 20, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Murad AtmacaErtan Tezcan
Jan 15, 2008·Schizophrenia Research·Tomás R GuilarteMartin G Pomper
Nov 11, 2003·Perspectives in Psychiatric Care·Bonnie Raingruber
Jul 18, 2008·Journal of Neurochemistry·Peethambaran ArunAryan M A Namboodiri
Apr 12, 2005·Schizophrenia Research·Emile G BruneauJames H Meador-Woodruff
Sep 5, 2006·Biological Psychiatry·Alessandro BertolinoTommaso Scarabino
Mar 15, 2000·Biological Psychiatry·M E WinsbergT A Ketter
Dec 18, 2001·Biological Psychiatry·D R WeinbergerT E Goldberg

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