PMID: 8945513Nov 29, 1996Paper

Regions responsible for the assembly of inwardly rectifying potassium channels

Cell
A TinkerL Y Jan

Abstract

Inwardly rectifying potassium channels have an important role in determining the resting potential of the cell. They are tetrameric proteins with two transmembrane segments (M1 and M2), a pore-forming loop (H5), a cytoplasmic N-terminal, and longer C-terminal domain. We have used biochemical and electrophysiological methods to identify regions required for homotypic interactions and those responsible for the incompatibility between IRK1 and two other members of the same subfamily (IRK2 and IRK3) and two members from other subfamilies (ROMK1 and 6.1 uK(ATP)). The data indicate that, in contrast to the voltage-gated class of potassium channel, the proximal C-terminus and the transmembrane segment M2 determine homo-and heteromultimerization and that heteromultimerization between members of the same or different subfamilies is case specific.

References

Sep 1, 1989·British Journal of Pharmacology·R A North
Oct 1, 1995·Physiological Reviews·K Wickman, D E Clapham
Oct 1, 1995·The American Journal of Physiology·Y Kurachi
Dec 1, 1994·Trends in Neurosciences·B Hille
Aug 22, 1995·Proceedings. Biological Sciences·E GlowatzkiB Fakler
Jun 1, 1995·Current Opinion in Neurobiology·C A DoupnikH A Lester
Sep 1, 1994·The Journal of General Physiology·Z Lu, R MacKinnon
Jun 1, 1994·Journal of Neurophysiology·L S Premkumar, P W Gage
Apr 1, 1994·Biophysical Journal·L HeginbothamR MacKinnon
Sep 8, 1994·Nature·L Y Jan, Y N Jan
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·N DascalD Trollinger
Jul 1, 1993·Neuron·N V ShenP J Pfaffinger
Jan 1, 1996·Physiological Reviews·K K DealM M Tamkun

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Citations

Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Amit S Dhamoon, José Jalife
Apr 12, 2003·Journal of Molecular and Cellular Cardiology·Meredith McLerieAnatoli Lopatin
Apr 12, 2003·Journal of Molecular and Cellular Cardiology·Yukio HosakaYoshifusa Aizawa
Apr 12, 2003·Journal of Molecular and Cellular Cardiology·Richard B Robinson, Jihong Qu
Jul 31, 2003·Progress in Biophysics and Molecular Biology·Anurag Varshney, M K Mathew
Aug 23, 2002·Pharmacology & Therapeutics·Alan Wickenden
Jan 16, 1998·Cellular Signalling·N Dascal
Jan 14, 2003·EMBO Reports·Michael SchwakeThomas Friedrich
Jul 29, 2010·Proceedings of the National Academy of Sciences of the United States of America·Andrew M PowlB A Wallace
Oct 23, 2010·The Journal of Biological Chemistry·Hyo Jeong KimEbenezer N Yamoah
Oct 26, 1999·The Journal of General Physiology·T P FlaggP A Welling
May 30, 2002·The Journal of General Physiology·Catherine A CukrasColin G Nichols
Nov 18, 1998·Current Opinion in Nephrology and Hypertension·C L Huang
Jul 22, 1999·Annals of the New York Academy of Sciences·W A CoetzeeB Rudy
Feb 5, 2002·Annual Review of Physiology·Carol Deutsch
Dec 25, 2004·Physiological Reviews·Steven C HebertWenhui Wang
May 17, 2003·The Journal of Clinical Investigation·Junichiro MiakeH Bradley Nuss
Oct 17, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laurent FerronAnnette C Dolphin
Jun 2, 2000·Biochemical and Biophysical Research Communications·F M Graves, A Tinker
Nov 15, 2013·Molecular Biology of the Cell·Alexander R KolbJeffrey L Brodsky
Aug 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·C CantíA C Dolphin
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Regina Preisig-MüllerJürgen Daut
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·T MikiS Seino
Jul 19, 2002·Proceedings of the National Academy of Sciences of the United States of America·Rona SadjaEitan Reuveny
Apr 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Haining ZhongKing-Wai Yau
Jul 22, 2014·Nature·Mingshan XueMassimo Scanziani
Feb 24, 2001·Journal of Molecular and Cellular Cardiology·J SeharaseyonE Marbán
Jul 13, 2001·Journal of Molecular and Cellular Cardiology·D J PountneyW A Coetzee
Feb 19, 2008·Current Opinion in Cardiology·Eduardo Marbán, Hee Cheol Cho
May 7, 2013·Basic Research in Cardiology·Maren M LimbergEric Schulze-Bahr
May 28, 2008·FEBS Letters·Yusong HeYi-Han Chen
Oct 22, 2008·Journal of Cellular Physiology·Stephanie B BoyerS V Penelope Jones
May 15, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jinfan ZhengChuanzhu Yan
Nov 20, 2008·The FEBS Journal·Zhiguang YuchiDaniel S C Yang

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