Regioselective access to CF₃S-substituted dihydrofurans from homopropargylic alcohols with trifluoromethanesulfenamide

Chemical Communications : Chem Comm
Dao-Qian ChenYong-Min Liang

Abstract

A facile access to 4-((trifluoromethyl)thio)-2,3-dihydrofurans from unprotected homopropargylic alcohols in high regioselectivity is reported. This method is the first example of using a free hydroxy group as a nucleophile to complete a trifluoromethylthiolation/cyclization protocol with an alkyne in moderate to excellent yields.

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Citations

Feb 18, 2016·Chemistry : a European Journal·Roman HonekerFrank Glorius
Jun 14, 2016·Organic & Biomolecular Chemistry·Yang YuXin-Shan Ye
Apr 12, 2017·Organic & Biomolecular Chemistry·Xiaodong Yang, Rulong Yan
Jun 2, 2015·Organic & Biomolecular Chemistry·Wei WuSong Cao
Aug 30, 2017·Chemical Communications : Chem Comm·Huan LiFeng-Ling Qing
Dec 14, 2017·Organic Letters·Quentin GlenadelThierry Billard
Oct 5, 2021·The Journal of Organic Chemistry·Debabrata MaitiSuman De Sarkar

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