Regioselective synthesis and antimicrobial screening of novel ketocarbazolodispiropyrrolidine derivatives

European Journal of Medicinal Chemistry
Govindasami PeriyasamiNarayanasamy Mathivanan

Abstract

A series of novel dispiropyrrolidine derivatives have been synthesized through 1,3-dipolar cycloaddition reaction of azomethine ylide generated from sarcosin and di/tri ketone with the dipolarophile (E)-2-arylidine-1-keto-carbazoles. The cycloadducts ketocarbazalo spiro N-methyl pyrrolidines showed the most interesting antimicrobial activity at lower concentration.

Citations

Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·R ArchanaR J Butcher
May 21, 2010·Bioorganic & Medicinal Chemistry Letters·Natarajan ArumugamNarayanasamy Mathivanan

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