Regioselective synthesis of 3-alkynyl-5-bromo-2-pyrones via Pd-catalyzed couplings on 3,5-dibromo-2-pyrone

Organic Letters
Jin-Hee LeeCheon-Gyu Cho

Abstract

[reaction: see text] 3,5-Dibromo-2-pyrone underwent facile Pd(0)-catalyzed coupling reactions with various alkynes to give rise to the corresponding 3-alkynyl-5-bromo-2-pyrones with good to excellent chemical yields and regioselectivity.

References

Sep 20, 1996·The Journal of Organic Chemistry·Zhi Liu, Jerrold Meinwald
Oct 25, 2001·The Journal of Organic Chemistry·Sulan YaoKarl Anker Jørgensen
Oct 25, 2001·The Journal of Organic Chemistry·Kimberly D. StigersPaul A. Bartlett
Oct 25, 2001·The Journal of Organic Chemistry·Richard C. LarockXiaojun Han
Jan 5, 2002·The Journal of Organic Chemistry·Cheon-Gyu ChoSangman Koo

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Citations

Apr 25, 2012·Investigational New Drugs·Jin Sun YoonYoung Yiul Lee
Jul 23, 2003·Bioorganic & Medicinal Chemistry Letters·Lester R MarrisonIan J S Fairlamb
Mar 26, 2015·Marine Drugs·Jong Seok Lee
Oct 15, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Michael J BurnsIan J S Fairlamb
Mar 25, 2006·Organic & Biomolecular Chemistry·Ian J S FairlambKing Chung Lam
Oct 3, 2006·Bioorganic & Medicinal Chemistry Letters·Sirisilla RajuManojit Pal
Nov 3, 2010·The Journal of Organic Chemistry·Frédéric FrébaultNuno Maulide
Sep 24, 2020·Organic Letters·Hyung-Joon KangCheon-Gyu Cho
Aug 23, 2019·Journal of the American Chemical Society·Vignesh PalaniRichmond Sarpong
Jan 17, 2019·Journal of the American Chemical Society·Vignesh PalaniRichmond Sarpong
Nov 20, 2003·Journal of the American Chemical Society·Won-Suk KimCheon-Gyu Cho
Dec 20, 2003·The Journal of Organic Chemistry·Soo-Jin PangCheon-Gyu Cho
Jul 14, 2006·Organic Letters·Jeong-Taek ShinCheon-Gyu Cho

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