PMID: 1319817Jul 15, 1992Paper

Regressing atypical histiocytosis, a regressing cutaneous phase of Ki-1-positive anaplastic large cell lymphoma. Immunocytochemical, nucleic acid, and cytogenetic studies of a new case in view of current opinion

Cancer
R J MotleyP J Holt

Abstract

Regressing atypical histiocytosis is a rare multifocal cutaneous tumor characterized by large, spontaneously regressing, ulcerating skin nodules. Although initially self-remitting, the condition may progress to systemic lymphoma. Using material from one patient, an attempt was made to clarify the nature of this condition with immunophenotyping, genotyping, and chromosome studies. Immunophenotyping studies indicated the condition was of T-cell lineage, although T-cell receptor gene studies showed polyclonal rearrangement. This case progressed to systemic lymphoma. The authors believe regressing atypical histiocytosis is a regressing phase of Ki-1-positive anaplastic large cell lymphoma of the skin.

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Citations

Nov 15, 1997·Microscopy Research and Technique·R V Lloyd, R Y Osamura
May 1, 1997·Journal of the American Academy of Dermatology·M F DemierreH K Koh
Jul 1, 1993·British Journal of Haematology·A Pizarro, J Pinilla
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Dec 1, 1993·Journal of Cutaneous Pathology·M R WickJ F Fitzgibbon
Feb 13, 2001·Biochemical and Biophysical Research Communications·S InoueY Ouchi
Jun 1, 1995·Leukemia & Lymphoma·S A PileriH Stein
Jul 10, 2004·Journal of the American Academy of Dermatology·James M ShehanIftikhar Ahmed
Oct 1, 1996·The Journal of Dermatology·H SakaiH Iizuka
May 1, 1995·The British Journal of Dermatology·J E HolderP E Hutchinson
Jan 6, 2011·Archives of Pathology & Laboratory Medicine·Marsha C KinneyEdward A Medina

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