Regression after subtotal resection of an optic pathway glioma in an adult without adjuvant therapy: case report

Journal of Neurosurgery
Eveline Teresa HidalgoJeffrey H Wisoff

Abstract

Optic pathway gliomas (OPGs) are relatively common and benign lesions in children; however, in adults these lesions are nearly always malignant and hold a very poor prognosis. In this report the authors present the case of an adult patient with a benign OPG who underwent subtotal resection without adjuvant therapy and has had no tumor progression for more than 20 years. A 50-year-old woman presented with a 2-year history of personality changes, weight gain, and a few months of visual disturbances. Ophthalmological evaluation showed incomplete right homonymous hemianopsia. MRI demonstrated a 2.5 × 2.5 × 2.5-cm enhancing left-sided lesion involving the hypothalamus with extension into the suprasellar cistern, extending along the left optic tract and anterior to the level of the optic chiasm. A biopsy procedure revealed a juvenile pilocytic astrocytoma. A subtotal resection of approximately 80% of the tumor was performed. Postoperatively, the patient experienced complete resolution of her personality changes, and her weight decreased back to baseline. Ophthalmological examination showed increased right homonymous hemianopsia. In the years following her surgery, there was a spontaneous decrease in tumor size without adjuvant therap...Continue Reading

References

Nov 1, 1990·Journal of Neurosurgery·J H WisoffF Epstein
Feb 1, 1980·American Journal of Ophthalmology·T C SpoorD Zorub
Mar 1, 1994·Survey of Ophthalmology·J J Dutton
Apr 1, 1997·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·H TakenchiT Kubota
Dec 5, 1998·Pediatric Neurosurgery·J C KernanA D'Agostino
Mar 6, 2004·International Journal of Radiation Oncology, Biology, Physics·Paul D BrownUNKNOWN Mayo Clinic
Apr 16, 2004·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Bettina WabbelsBirgit Lorenz
Feb 24, 2007·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·T T DinhM Cherny
Nov 17, 2007·Neurosurgical Focus·Mandy J BinningMarion L Walker
May 10, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Selma MatloobHelen V Danesh-Meyer
Jun 25, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Ye LiuYuncheng Wu
Oct 22, 2013·Journal of Neurosurgery. Pediatrics·John GooddenConor Mallucci
Dec 18, 2013·Neurosurgery·Ben ShoftyAnat Kesler
May 26, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ghislaine L TraberKlara Landau

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
dissection

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

Journal of Neurosurgery. Pediatrics
Garrett K ZoellerDavid I Sandberg
Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Masaya NagaishiAkio Hyodo
Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Satoshi TsutsumiMasanori Ito
Neurosurgery
Ben ShoftyAnat Kesler
© 2022 Meta ULC. All rights reserved