PMID: 308987Sep 1, 1978Paper

Regression and inhibition of sarcoma growth by interference with a radiosensitive T-cell population

The Journal of Experimental Medicine
K E HellströmJ D Tamerius

Abstract

BALB/c mice were inoculated subcutaneously with 10(6) cells from either of two syngeneic sarcomas 1315 and 1425. 6--8 days later, the mice were randomized into groups which were left untreated or given 400 rads of whole body irradiation. Irradiation significantly retarded the growth of both sarcomas, and complete regressions were seen of approximately equal to 30% of the small, established 1315 tumors. The anti-tumor effect of irradiation was abolished if the irradiated mice were inoculated with a T-cell-enriched (but not with a T-cell deprived) suspension of syngeneic spleen cells, suggesting that the irradiation inhibited tumor growth by affecting a radiosensitive population of host suppressor T cells.

References

Mar 15, 1978·International Journal of Cancer. Journal International Du Cancer·K E HellströmJ P Brown
Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·C L ReinischS F Schlossman
Feb 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J P BrownK E Hellström
Jan 15, 1975·International Journal of Cancer. Journal International Du Cancer·S B HowellL W Law
Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·M I GreeneB Benacerraf
Nov 1, 1972·International Journal of Cancer. Journal International Du Cancer·M HayamiK Yamanouchi
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Apr 14, 1972·Science·Richmond T Prehn

Citations

Mar 15, 1983·Experientia·G T NepomK E Hellström
Jan 25, 2005·Springer Seminars in Immunopathology·Roberto BaccalaArgyrios N Theofilopoulos
Mar 5, 1998·International Journal of Radiation Oncology, Biology, Physics·M HareyamaK Morita
Dec 14, 1978·The New England Journal of Medicine·S Broder, T A Waldmann
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·I HellströmI D Bernstein
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·A F TilkinJ Urbain
Dec 3, 2009·Journal of Immunotherapy·Pu LiuK E Hellström
Aug 12, 1993·Annals of the New York Academy of Sciences·I Hellström, K E Hellström
Sep 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chrystal M PaulosNicholas P Restifo
Jul 18, 2002·The Journal of Clinical Investigation·Gabriel N Maine, J J Mulé
Jul 20, 2010·Immunotherapy·Michael J Gough, Marka R Crittenden
Jun 27, 2013·Theoretical Biology & Medical Modelling·Richmond T Prehn, Liisa M Prehn
Jan 1, 1992·Cancer Investigation·K E Hellström, I Hellström
Nov 1, 1981·International Journal of Radiation Oncology, Biology, Physics·L E KunV D Piaskowski
Sep 16, 2008·Best Practice & Research. Clinical Haematology·Katayoun Rezvani, A John Barrett
Apr 1, 1997·Medical Hypotheses·J Eldor
Apr 1, 1982·European Journal of Cancer & Clinical Oncology·M BertschmannE F Lüscher
Jan 1, 1981·Neuropathology and Applied Neurobiology·A M Spence, G Priestley
Dec 27, 2005·Seminars in Cancer Biology·Rimas J OrentasBryon D Johnson
Jun 24, 2015·Journal of Immunology Research·Michelle H NelsonChrystal M Paulos
Feb 26, 2003·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·K E Hellström, I Hellström
Jan 9, 2004·Expert Review of Vaccines·K E Hellström, I Hellström
Sep 1, 2007·Cancer·Elizabeth A MittendorfS Eva Singletary
Jun 12, 2003·British Journal of Cancer·R HandgretingerD Niethammer
Apr 15, 1979·International Journal of Cancer. Journal International Du Cancer·I HellströmJ P Brown
Jun 15, 1980·International Journal of Cancer. Journal International Du Cancer·W E Enker, J L Jacobitz
May 1, 1993·International Journal of Radiation Biology·Y HosoiK Sakamoto
Aug 10, 2017·Frontiers in Oncology·Sean M O'CathailMaria A Hawkins
Apr 27, 2017·Frontiers in Immunology·Dörthe Schaue
Jan 1, 1983·Cancer Metastasis Reviews·P Frost, R S Kerbel
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Angela M TatumTodd D Schell
Dec 15, 1982·International Journal of Cancer. Journal International Du Cancer·I DamjanovD Solter

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.