Regression of canine oral papillomas is associated with infiltration of CD4+ and CD8+ lymphocytes

Virology
P K NichollsM A Stanley

Abstract

Canine oral papillomavirus (COPV) infection is used in vaccine development against mucosal papillomaviruses. The predictable, spontaneous regression of the papillomas makes this an attractive system for analysis of cellular immunity. Immunohistochemical analysis of the timing and phenotype of immune cell infiltration revealed a marked influx of leukocytes during wart regression, including abundant CD4+ and CD8+ cells, with CD4+ cells being most numerous. Comparison of these findings, and those of immunohistochemistry using TCRalphabeta-, TCRgammadelta-, CD1a-, CD1c-, CD11a-, CD11b-, CD11c-, CD18-, CD21-, and CD49d-specific monoclonal antibodies, with previously published work in the human, ox, and rabbit models revealed important differences between these systems. Unlike bovine papillomavirus lesions, those of COPV do not have a significant gamma/delta T-cell infiltrate. Furthermore, COPV lesions had numerous CD4+ cells, unlike cottontail rabbit papillomavirus lesions. The lymphocyte infiltrate in the dog resembled that in human papillomavirus lesions, indicating that COPV is an appropriate model for human papillomavirus immunity.

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Citations

Apr 12, 2012·Clinical Microbiology Reviews·Margaret A Stanley
Sep 20, 2002·Journal of Virology·Woei Ling PehJohn Doorbar
Oct 29, 2010·Journal of Translational Medicine·Luciano Mariani, Aldo Venuti
Oct 16, 2001·Journal of Reproductive Immunology·M A Stanley
Mar 9, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·John Doorbar
Nov 9, 2011·Journal of Immunotoxicology·Hervé LebrecPeter Moore
Dec 5, 2012·Vaccine·John DoorbarMargaret A Stanley
Sep 25, 2015·The Journal of General Virology·Jiafen HuNeil D Christensen
Jun 14, 2008·Gynecologic Oncology·Margaret Stanley
Jul 24, 2007·Veterinary Immunology and Immunopathology·Hans-Joachim SchuberthMartin Faldyna
May 9, 2006·Dermatologic Clinics·Ammar M AhmedStephen K Tyring
Jul 28, 2015·Biologicals : Journal of the International Association of Biological Standardization·Anoop KumarMausumi Bharadwaj
May 20, 2006·Reviews in Medical Virology·Margaret A Stanley
Nov 28, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·Y L WooM Stanley
Aug 14, 2012·Veterinary Ophthalmology·K Tomo WiggansJuliet R Gionfriddo
Mar 11, 2015·Reviews in Medical Virology·John DoorbarIsao Murakami
Mar 9, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Peter L Stern
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Sep 5, 2006·Virology·Suchitra JainMargaret A Stanley
Oct 14, 2003·Virology·Richard A MooreMargaret A Stanley
Feb 18, 2017·Genetics and Molecular Biology·Rodrigo Pinheiro AraldiWilly Beçak
Jan 2, 2004·The Annals of Otology, Rhinology, and Laryngology·Babak Jahan-ParwarGerald S Berke
Dec 3, 2002·Human & Experimental Toxicology·P J Felsburg

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