PMID: 2485021Jan 1, 1987Paper

Regression of cardiac hypertrophy: experimental and clinical results

Journal of Cardiovascular Pharmacology
W MotzB E Strauer

Abstract

Since left ventricular hypertrophy is considered to be a precursor of later hypertensive heart failure, a treatment that can prevent or even reverse myocardial hypertrophy is a highly desirable goal. In order to evaluate which type of antihypertensive treatment is able to induce regression of hypertensive hypertrophy, experimental and clinical studies were performed. Experimental studies were performed in spontaneously hypertensive rats (SHRs). Left ventricular hypertrophy and pumping function were studied after antihypertensive treatment with a beta-receptor blocker (metoprolol), an arteriolar vasodilator (hydralazine), and a calcium channel blocker (nifedipine) had been instituted for a period of 20-40 weeks. Patients with hemodynamically compensated hypertensive heart disease were treated with a calcium channel blocker (nifedipine), an angiotensin-converting enzyme (ACE) inhibitor (enalapril), an antisympathetic agent (clonidine), and prazosin. Comparing the amount of blood pressure reduction with the extent of hypertrophy reversal, nifedipine, prazosin, and enalapril were equipotent, whereas clonidine was most efficient in this respect. Muscle mass was overproportionally reduced in relation to blood pressure reduction follo...Continue Reading

Citations

Dec 30, 1999·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·D GrimmE P Kromer
May 26, 2012·Journal of Cardiovascular Pharmacology and Therapeutics·A Baraka, S El Ghotny
May 23, 2006·Journal of Molecular and Cellular Cardiology·Tushi SingalParamjit S Tappia

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