Regression of coronary atherosclerosis by simvastatin: a serial intravascular ultrasound study

Circulation
Lisette Okkels JensenTorben Haghfelt

Abstract

Angiography of the coronary arteries reflects only changes in luminal dimensions. With intravascular ultrasound, cross-sectional images can be obtained and area measurements can be added to calculate volumes of the external elastic membrane (EEM), plaque plus media (P+M), and lumen. The aim of this study was to investigate the effect of lipid lowering by simvastatin on coronary atherosclerotic P+M as changes in volumes of EEM, P+M, and lumen. In 40 male patients with hypercholesterolemia, ischemic heart disease, and a nonsignificant coronary artery lesion in a not previously revascularized coronary artery, serial intravascular ultrasound studies with an ECG-triggered pullback were performed at baseline, after 3 months on a lipid-lowering diet, and after another 12 months on simvastatin 40 mg/d. Mean length of the analyzed atherosclerotic segments was 5.9+/-3.3 mm. After 12 months on simvastatin, a significant reduction in P+M volume of 6.3% (P=0.002) was observed, whereas only a nonsignificant reduction in EEM volume of 1.8% was seen without any concomitant change in lumen volume. A significant reduction in total cholesterol of 31.0% (6.1+/-0.8 versus 4.2+/-0.7 mmol/L, P<0.001) and LDL cholesterol of 42.6% (4.0+/-0.8 versus 2.2...Continue Reading

References

May 28, 1987·The New England Journal of Medicine·S GlagovG J Kolettis
Sep 1, 1994·Journal of the American Dietetic Association·J R PetersD B Hunninghake
Nov 15, 1993·Annals of Internal Medicine·D H BlankenhornUNKNOWN MARS Research Group
Mar 13, 2001·The American Journal of Cardiology·S Nissen
Nov 6, 2003·JAMA : the Journal of the American Medical Association·Steven E NissenRichard Kerensky
Nov 25, 2004·International Journal of Cardiology·Lisette Okkels JensenTorben Haghfelt

❮ Previous
Next ❯

Citations

Nov 3, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Nader N Boushra, Muhammad Muntazar
Dec 20, 2005·The International Journal of Cardiovascular Imaging·Gastón A Rodriguez-GranilloPatrick W Serruys
Mar 5, 2011·The International Journal of Cardiovascular Imaging·Bill D GogasHector M Garcìa-Garcìa
Jan 5, 2008·Current Atherosclerosis Reports·Stephen J NichollsSteven E Nissen
Sep 17, 2010·Current Atherosclerosis Reports·Stanley F Fernandez, William E Boden
Dec 20, 2012·Current Atherosclerosis Reports·Mukesh Singh, Updesh Singh Bedi
Feb 9, 2006·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ilke SipahiE Murat Tuzcu
Jul 1, 2006·Nature Clinical Practice. Cardiovascular Medicine·Jean-Claude Tardif, Therese Heinonen
Mar 2, 2005·Nature Reviews. Drug Discovery·Patrick Linsel-Nitschke, Alan R Tall
May 16, 2006·Nature Reviews. Drug Discovery·Stephen J NichollsSteven E Nissen
Sep 9, 2010·European Heart Journal·Hector M Garcia-GarciaPatrick W Serruys
Dec 17, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hideki IshiiToyoaki Murohara
Mar 16, 2005·Current Opinion in Lipidology·Mike F Laker
Jul 14, 2009·Current Opinion in Lipidology·Stephen J Nicholls
May 17, 2007·International Journal of Clinical Practice·S R KalidindiS J Nicholls
Sep 4, 2012·BMC Cardiovascular Disorders·Jinwei TianBo Yu
Oct 30, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroaki TakashimaTakayuki Ito
May 15, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Naoki NozawaKazuo Kimura
Nov 19, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Atsushi IwataKeijiro Saku
Apr 13, 2005·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Camillo SherifMartin Schillinger
Jul 25, 2006·AJR. American Journal of Roentgenology·Kevin M JohnsonJames A Brink
Dec 1, 2008·Biomarkers in Medicine·Stéphane NobleJean-Claude Tardif
Aug 19, 2009·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Stephan GielenDaniel Teupser
Nov 1, 2006·Future Cardiology·Jeffrey S BergerHarry R Phillips
Mar 1, 2007·Future Cardiology·Stephen J NichollsPia Lundman
Sep 17, 2013·The Journal of Thoracic and Cardiovascular Surgery·Ying Yan ZhuPhilip A Hayward
Aug 16, 2008·The International Journal of Cardiovascular Imaging·Marc HartmannClemens von Birgelen
May 2, 2014·European Heart Journal Cardiovascular Imaging·Yu KataokaStephen J Nicholls
Feb 6, 2010·AJNR. American Journal of Neuroradiology·H ZacharatosA I Qureshi
Feb 18, 2006·Free Radical Research·Ntei AbuduStanley S Levinson
Jun 10, 2009·Expert Review of Cardiovascular Therapy·Umar SadatKevin Varty
Sep 1, 2007·Expert Opinion on Drug Discovery·Stephen J NichollsSteven E Nissen

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.