PMID: 9555800Apr 29, 1998Paper

Regression of Kaposi's sarcoma during therapy with HIV-1 protease inhibitors: a prospective pilot study

Journal of the American Academy of Dermatology
J KrischerM Pechère

Abstract

Early studies using HIV protease inhibitors (PI) showed regression of Kaposi's sarcoma (KS) lesions in some patients. Our purpose was to determine prospectively the influence of PI on HIV-related KS. KS lesions of nine patients with progressive cutaneous disease were prospectively evaluated clinically and by means of epiluminescence microscopy before and during PI therapy. HIV viremia and CD4 cell count were measured in parallel. All patients experienced reduction or initial stabilization of KS lesions during the first 4 to 8 weeks of HIV-1 PI therapy. After a median follow-up of 7 months and according to AIDS Clinical Trials Groups criteria, six patients had a partial response, two showed stable disease, and in one noncompliant patient KS progressed, requiring chemotherapy. With epiluminescence microscopy, a reduction in skin surface alterations, lesional size, and color intensity was demonstrated in six of nine patients. PI induced a median decrease in viremia of 1.66 log and a median increase in the CD4 count of 49 cells/mm3. In this series, HIV PI therapy reduced or stabilized KS. The efficacy of HIV-1 PI in KS may result from the improvement in cellular immunity. These results suggest the use of PI in AIDS-related KS regar...Continue Reading

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Citations

Oct 12, 2000·Clinics in Dermatology·P Whelan, D T Scadden
Jan 6, 2001·Infectious Disease Clinics of North America·P G O'Connor, D T Scadden
Jun 15, 2007·Journal of the National Cancer Institute·Robert J BiggarUNKNOWN HIV/AIDS Cancer Match Study
Jun 13, 2009·Future Oncology·Gary M Clifford, Silvia Franceschi
Jan 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan E Krown
Apr 6, 1999·Cancer Treatment Reviews·G SchwartsmannR U Villarroel
Dec 20, 2002·Clinics in Laboratory Medicine·Monica Gandhi, Ruth M Greenblatt
Jun 12, 2008·Journal of Cutaneous Medicine and Surgery·Sanjeev HandaAjay Wanchu
Apr 22, 2005·Dermatologic Therapy·Karl WilkinsToby A Maurer
May 15, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·S C-S HuS-T Cheng
Jan 5, 2011·The Australasian Journal of Dermatology·Dougal Coates, Jonathan Bowling
Dec 2, 2005·Dermatology : International Journal for Clinical and Investigative Dermatology·Iris ZalaudekHelmut Kerl
Aug 31, 2016·EMBO Reports·Aude De GassartFabio Martinon
Dec 17, 2003·Journal of Cutaneous Pathology·Liron PantanowitzSteven R Tahan
Jan 5, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·S Handa, J S Bingham
Jun 5, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Vassilios A PaparizosNikolaos G Stavrianeas
Jun 6, 2003·International Journal of Dermatology·Giuseppe Micali, Francesco Lacarrubba
Aug 2, 2019·International Journal of Molecular Sciences·Thajasvarie NaickerJagidesa Moodley
Aug 22, 2000·Postgraduate Medicine·R T Brodell
Nov 25, 2020·Cancers·Mahbuba R Subeha, Carlos M Telleria
Dec 2, 2021·Journal of the National Cancer Institute·Daniel DiMaioAmy Justice

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