Regression of left ventricular hypertrophy and prevention of stroke in hypertensive subjects

American Journal of Hypertension
Paolo VerdecchiaGian Paolo Reboldi

Abstract

Left ventricular hypertrophy (LVH) is a risk marker for stroke and its regression confers protection from stroke. The relationship between serial LVH changes and risk of stroke has never been investigated in a mixed population of hypertensive subjects with and without LVH. In this study, 880 initially untreated hypertensive subjects (mean age 48 years, office blood pressure (BP) 155/98 mm Hg; 24-h BP 137/87 mm Hg) underwent tests including echocardiography and 24-h ambulatory BP monitoring at entry and after a median of 3.5 years, still in the absence of cardiovascular events. Months or years after the follow-up study, 34 of these subjects developed a first cerebrovascular event (stroke in 21, transient ischemic attack in 13). Event rate (x 100 patients per year) was 0.25 among the subjects who never developed echocardiographic LVH or with regression of LVH, versus 1.16 among the subjects with lack of regression or new development of LVH (log-rank test: P = .00001). Serial electrocardiogram (ECG) changes failed to define groups at different risk. In a Cox analysis, the risk of cerebrovascular events was 2.8 times higher (95% CI: 1.18-6.69) in the subset with lack of regression or new development of LVH than in that with LVH reg...Continue Reading

Citations

Dec 18, 2012·International Archives of Medicine·Chaturaka RodrigoGodwin Constantine
Apr 26, 2008·American Journal of Hypertension·Luis M Ruilope, Roland E Schmieder
Apr 24, 2010·American Journal of Hypertension·Sante D Pierdomenico, Franco Cuccurullo
Sep 11, 2016·Progress in Cardiovascular Diseases·Ahmet Afşin OktayMichael E Cash
Jan 30, 2007·Der Internist·M G Hennersdorf, B E Strauer
Feb 23, 2013·Cerebrovascular Diseases·Gianpaolo ReboldiPaolo Verdecchia
Jun 9, 2007·Current Opinion in Cardiology·Paolo VerdecchiaClaudio Cavallini
Jun 4, 2008·Current Opinion in Cardiology·Burkert Pieske, Rolf Wachter
Jun 22, 2010·Der Internist·M HennersdorfW Motz
Jun 10, 2009·Expert Review of Cardiovascular Therapy·Veeran Subramaniam, Gregory Y H Lip
Jun 6, 2019·Future Cardiology·Robert J Henning
Oct 29, 2013·Current Cardiology Reports·Richard G Kiel, Prakash Deedwania
Mar 21, 2009·Journal of Hypertension·Cesare Cuspidi
Sep 4, 2015·Journal of Hypertension·Fabio AngeliUNKNOWN MAVI Investigators
Oct 4, 2013·The Journal of Clinical Hypertension·Gadi ShlomaiGiuseppe Mancia
Sep 14, 2012·Journal of Hypertension·Massimo VolpeAllegra Battistoni
Feb 1, 2019·Journal of Hypertension·Marijana Tadic
Aug 5, 2020·Journal of the American Heart Association·Saadat KamranJonathan D Perkins
Nov 16, 2012·Journal of Hypertension·Fabio AngeliPaolo Verdecchia
Jun 4, 2021·Current Cardiology Reports·Ramachandran S VasanVanessa Xanthakis
Jul 6, 2021·The Journal of Clinical Endocrinology and Metabolism·My-Le NguyenRebecca J Brown
May 15, 2021·Panminerva Medica·Paolo VerdecchiaFabio Angeli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.