Regression of left ventricular hypertrophy and aortic remodelling in NO-deficient hypertensive rats: effect of L-arginine and spironolactone

Acta Physiologica
L PaulisF Simko

Abstract

We investigated, whether the substrate for nitric oxide (NO) formation -L-arginine - and the aldosterone receptor antagonist - spironolactone - are able to reverse alterations of the left ventricle (LV) and aorta in N(omega)-nitro-L-arginine methyl ester (L-NAME)-induced hypertension. Six groups of male adult Wistar rats were investigated: controls after 4 and 7 weeks of experiment, rats treated with L-NAME for 4 weeks and three recovery groups: spontaneous-reversion (4 weeks L-NAME + 3 weeks placebo), spironolactone-induced reversion (4 weeks L-NAME + 3 weeks spironolactone) and L-arginine-induced reversion (4 weeks L-NAME+ 3 weeks L-arginine). Blood pressure was measured by tail-cuff plethysmography. Relative weight of the LV, myocardial fibrosis (based upon histomorphometry and hydroxyproline determination) and conjugated dienes in the LV and aortic cross-sectional area, inner diameter and wall thickness were determined. NO-synthase activity was investigated in the LV and aorta. L-NAME administration induced hypertension, left ventricular hypertrophy (LVH), LV fibrosis, aortic thickening and diminution of NO-synthase activity in the LV and aorta. Reduction in blood pressure and regression of LVH were observed in all recovery...Continue Reading

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Citations

Jul 26, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Xuan XiongLe-Xin Wang
Dec 4, 2010·Pathophysiology : the Official Journal of the International Society for Pathophysiology·M KhazaeiA A Pourshanazari
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Jan 1, 2010·Journal of Pineal Research·Ludovit PaulisFedor Simko
Jan 15, 2016·Clinical Journal of the American Society of Nephrology : CJASN·David M CharytanUNKNOWN MiD Investigators and Committees
Sep 25, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·David M Charytan
Oct 9, 2014·Current Opinion in Nephrology and Hypertension·David Charytan
Jun 4, 2016·Physiological Reports·Jonathan CaronJean-Jacques Boffa
Oct 27, 2017·European Journal of Medical Research·Peter SabakaFedor Simko
Aug 2, 2017·International Journal of Molecular Sciences·Fedor SimkoMichaela Adamcova
Sep 5, 2018·International Journal of Molecular Sciences·Ashfaq AhmadJoseph K Ritter

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