Regression of organ damage following renal denervation in resistant hypertension: a meta-analysis

Journal of Hypertension
Athanasios KordalisChristodoulos Stefanadis

Abstract

Prospective observational studies have suggested that renal denervation (RDN) is associated with target organ damage (TOD) regression. Our aim is to review and meta-analyze the available evidence for the effect of RDN on TOD. We searched literature for studies with eligible content and performed random-effect meta-analyses for the following outcomes: left ventricular mass index (LVMI), left atrial volume index (LAVI), E to A wave velocities of trans-mitral inflow (E/A) and E wave velocity to Em velocity from tissue Doppler imaging (E/Em), central augmentation index (AIx) and carotid-femoral pulse wave velocity (PWV). Seventeen studies (n = 698 patients) were incorporated in the present meta-analysis. RDN led to a regression of LVMI by 14.17 g/m (95% CI -18.33 to -10.01, P < 0.001) and by 4.75 g/m (95% CI -7.83 to -1.67, P = 0.003) for echocardiography and cardiac magnetic resonance, respectively. The pooled effect of RDN to E/A was not significant [0.04 (95% CI -0.03 to 0.12, P = 0.252)], whereas a decline of E/Em [-0.73 (95% CI -1.38 to -0.08, P = 0.03)] was observed. The pooled effect to LAVI [-1.67 ml/m (95% CI -4.60 to 1.27, P = 0.266)] reached statistical significance only in sensitivity analysis. RDN had beneficial effect...Continue Reading

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Citations

Oct 2, 2019·American Journal of Hypertension·Michael KunzFelix Mahfoud
Apr 15, 2020·Nature Reviews. Cardiology·Lucas LauderFelix Mahfoud
Sep 6, 2020·Current Hypertension Reports·Maximillian T Bourdillon, Ramachandran S Vasan
Jan 15, 2019·Journal of Hypertension·Sebastian VölzUNKNOWN all authors
Jan 15, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Norihiko MorisawaAkira Nishiyama
Jul 17, 2020·Frontiers in Physiology·Maria Teresa La RoverePeter J Schwartz
Feb 16, 2021·Progress in Cardiovascular Diseases·Lucas LauderFelix Mahfoud

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