Regression of Papillary Thyroid Cancer during Nivolumab for Renal Cell Cancer

European Thyroid Journal
Andrea PalermoDaniele Santini

Abstract

Immune checkpoint inhibitors have been recently approved for cancer treatment. Nivolumab is a monoclonal antibody specific for programmed cell death-1 (PD-1) that modulates T-cell response. It was initially used for the treatment of malignant melanoma and then approved in other cancers, such as non-small cell lung cancer and clear cell renal cell carcinoma (ccRCC). So far, the activity of nivolumab in patients with thyroid malignancies has been reported in a single case of anaplastic thyroid cancer. Here, we report the case of a patient with ccRCC who developed a papillary thyroid carcinoma (PTC) under first-line sunitinib treatment. During nivolumab, the second-line treatment for ccRCC, we unexpectedly observed a complete regression of PTC.

References

Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R J MotzerJ Ferrara
Jan 5, 2007·Journal of the National Cancer Institute·Brian I RiniRonald M Bukowski
Jan 27, 2012·The Journal of Clinical Endocrinology and Metabolism·Emilio Fiore, Paolo Vitti
May 3, 2014·Journal of Endocrinological Investigation·Francesco NardiPaolo Vitti
May 17, 2014·European Journal of Endocrinology·Frédéric IllouzPatrice Rodien
Jan 22, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael A PostowJedd D Wolchok
Mar 24, 2015·Future Oncology·Julie R BrahmerEvan J Lipson
Sep 26, 2015·The New England Journal of Medicine·Robert J MotzerUNKNOWN CheckMate 025 Investigators
Sep 15, 2016·The New England Journal of Medicine·James A Fagin, Samuel A Wells
Nov 9, 2016·Thyroid : Official Journal of the American Thyroid Association·Rong-Liang ShiQing-Hai Ji
Nov 23, 2016·Annals of Surgical Oncology·Iain J NixonAlfio Ferlito
Jan 18, 2017·Endocrine-related Cancer·Soomin AhnJae Hoon Chung
Aug 6, 2017·The Oncologist·Revathi KolliparaPatrick J Kiel
Oct 11, 2017·Journal of Pathology and Translational Medicine·Hyo Jung AnDae Hyun Song
Dec 16, 2017·Expert Review of Anticancer Therapy·Alessandro AntonelliPoupak Fallahi
Apr 5, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nikita PozdeyevDaniel W Bowles
Aug 21, 2018·International Journal of Endocrinology·Chiara TuccilliSalvatore Ulisse
Aug 23, 2018·Thyroid : Official Journal of the American Thyroid Association·Priyanka C IyerRamona Dadu

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