PMID: 20623469Jul 14, 2010Paper

Regression of peripapillary choroidal neovascularization after oscillatory transpupillary thermotherapy and anti-VEGF pharmacotherapy

European Journal of Ophthalmology
Gholam PeymanMandi Conway

Abstract

We prospectively evaluated a new treatment for recalcitrant choroidal neovascularization (CNV) in 4 patients. We used an infrared laser (810 nm) in oscillatory thermotherapy (OTT) mode combined with indocyanine green (ICG) dye, utilizing the beneficial effect of both thermotherapy and photodynamic therapy. We describe preliminary experiences with ICG-assisted OTT (I-OTT) combined with intravitreal bevacizumab/dexamethasone for refractory peripapillary CNV resistant to standard therapy. Clinical examination, funduscopy, fluorescein angiography, and optical coherence tomography were performed at baseline and postoperatively. Infrared laser spot size was approximately one-half the lesion size (oscillation 2-3 Hz). Intravitreal injections of bevacizumab (1.25 mg) and dexamethasone (1000 µg) were done during the same visit. Mean follow-up was 12.5 months (range 5-17). Mean energy level was 325 mW (range 200-500) in oscillatory mode (2-3 Hz/sec) pre- and post-ICG infusion. Indocyanine green dose was approximately 1 mg/kg (75 mg/patient). All patients had a single treatment. Mean visual acuity improved in 1 patient from 20/60 to 20/30 and remained the same in the other 3 (20/20, 20/40, and 20/400). At final examination, there was no e...Continue Reading

References

Mar 11, 1976·Nature·W T HamD H Sliney
Jan 15, 1988·American Journal of Ophthalmology·J C Kies, A C Bird
Sep 30, 1988·Science·M F BarbeW J Welch
Aug 1, 1994·Archives of Ophthalmology·A CaponeT A Meredith
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·B S PollaA Cossarizza
Apr 1, 1997·Archives of Ophthalmology·L A YannuzziD A Orlock
Mar 21, 1998·Journal of Magnetic Resonance Imaging : JMRI·R StollbergerF Ebner
Jan 8, 1999·Cell Stress & Chaperones·A Samali, S Orrenius
Nov 24, 1999·Archives of Ophthalmology·L A YannuzziD A Orlock
Jan 27, 2000·Ophthalmology·G A PeymanD M Moshfeghi
Feb 13, 2001·The British Journal of Ophthalmology·R S NewsomJ D McHugh
Jun 5, 2001·Current Opinion in Ophthalmology·A H Rogers, E Reichel
Oct 9, 2001·American Journal of Ophthalmology·R A CostaJ A Cardillo
Nov 21, 2002·Retina·Richard F SpaideK Bailey Freund
Feb 13, 2003·Ophthalmology·Brian P ConnollyHeidi Moran
Apr 26, 2003·Investigative Ophthalmology & Visual Science·Benedetto FalsiniMartin A Mainster
Sep 26, 2003·Investigative Ophthalmology & Visual Science·Ursula Schmidt-ErfurthGottfried O H Naumann
Aug 11, 2006·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Judy E KimThomas B Connor
Jul 16, 2008·The British Journal of Ophthalmology·M S FigueroaI Contreras
Jan 6, 2009·European Journal of Ophthalmology·A E HoehS Dithmar
Jul 9, 2009·Retina·Albert Augustin

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