Regression of polyneural innervation in the human psoas muscle

Early Human Development
A GramsbergenM Hadders-Algra

Abstract

During the early stages of mammalian ontogeny muscle fibres are innervated by more than one axon. This polyneural innervation is replaced by mononeural innervation in the course of development. The regression of polyneural innervation in the psoas muscle in the human is the topic of the present study. Innervation patterns were studied in fetuses from 15 1/2 weeks of post menstrual age (PMA) and in babies until 80 weeks PMA (40 weeks after term age) and compared to data from two adults. Motor endplates were stained by a combined acetylcholinesterase stain. Innervation patterns and motor endplate morphology were studied and the sizes of endplates were measured. As a main result of our study polyneural innervation of the psoas muscle remains at a level of about 2 endings per endplate (range 1-5 terminals) until 18-25 weeks PMA and decreases thereafter. From 52 weeks PMA (12 weeks post term) onwards, muscle fibres are predominantly mononeurally innervated. During development the morphology of the terminal patterns of the nerve endings becomes more complex and the size of endplates increases, implying that the adult pattern of muscle innervation is reached at the age at which a major functional transformation in the neurobehavioural...Continue Reading

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Citations

Jul 9, 1998·Muscle & Nerve·J Ijkema-Paassen, A Gramsbergen
Oct 21, 2006·Pediatric Physical Therapy : the Official Publication of the Section on Pediatrics of the American Physical Therapy Association·M Hadders-Algra
Oct 18, 2005·Birth Defects Research. Part A, Clinical and Molecular Teratology·Pamela David, Krishnan Subramaniam
Jan 4, 2005·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Scott A Croes, Christopher S von Bartheld
Feb 11, 2014·Annals of Clinical and Translational Neurology·W David ArnoldArthur H M Burghes
Feb 26, 2000·Developmental Psychobiology·J VaalB Hopkins
Jan 20, 2010·The Journal of Urology·Kevin R Loughlin, Michaella M Prasad
Jul 26, 2019·Journal of Speech, Language, and Hearing Research : JSLHR·Hannah E Epperson, Mary J Sandage
Apr 3, 2014·Physiological Reviews·Ildiko Szabo, Mario Zoratti
Aug 15, 2019·Journal of Neurophysiology·Clarissa F CavarsanKatharina A Quinlan

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