PMID: 3758685Jan 1, 1986Paper

Regression of posterior uveal malignant melanomas after cobalt plaque radiotherapy

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
J J AugsburgerJ L Day

Abstract

We reviewed the records of 17 patients with posterior uveal malignant melanoma who had been followed for at least 3 months prior to cobalt plaque radiotherapy and whose tumor had been documented to enlarge in thickness during that interval. We evaluated the relationship between the rates of pretreatment tumor enlargement and post-treatment tumor shrinkage using linear regression analysis. We found that the rate of postirradiation tumor shrinkage correlated strongly with the rate of preirradiation tumor enlargement regardless of whether the pretreatment rate of growth was slow, intermediate or rapid. We speculate that the more rapidly regressing tumors were more mitotically active than their more slowly regressing counterparts. If true, the survival rate of patients whose posterior uveal malignant melanomas regress rapidly following radiation therapy may prove to be worse than that of patients whose tumors regress slowly.

References

Sep 1, 1978·Archives of Ophthalmology·E S GradoudasK N Johnson
Jun 1, 1976·The British Journal of Radiology·R SealyD Sevel
Oct 1, 1982·Ophthalmology·J A ShieldsJ L Day
Feb 1, 1980·American Journal of Ophthalmology·D H CharA Schwartz
Jun 1, 1980·Ophthalmology·D H CharA Schwartz

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Citations

Jan 1, 1990·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·G WollensakH Fritz-Niggli
Jun 1, 1990·The British Journal of Ophthalmology·D H AbramsonE Zang
Jun 15, 1986·American Journal of Ophthalmology·D F GoodmanJ R Castro
May 23, 2001·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·H LakoshaR Simpson
Mar 1, 1992·International Ophthalmology·W A Manschot, R van Strik
Aug 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M KleineidamS M Bentzen
Apr 20, 2004·International Journal of Radiation Oncology, Biology, Physics·Khaled EmaraE Rand Simpson
Aug 16, 2001·Optometry and Vision Science : Official Publication of the American Academy of Optometry·D S LeeJ C Townsend
May 24, 2018·European Journal of Ophthalmology·Abhilasha Maheshwari, Paul T Finger
May 1, 1989·Australian and New Zealand Journal of Ophthalmology·M E GiblinL W Brady

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