Regression on oxymetholone-induced hepatic tumors after bone marrow transplantation in aplastic anemia

Transplantation
R R MontgomeryM L Johnson

Abstract

Treatment of acquired aplastic anemia with androgens has been occasionally associated with the development of hepatic tumors. We have studied a 13-year-old boy with idiopathic aplastic anemia in whom oxymetholone treatment was associated with a partial hematological remission. Thirty-four months later, however, the patient developed multiple hepatic tumors. When oxymetholone therapy was discontinued, the aplastic anemia relapsed. He then underwent bone marrow transplantation from his HLA-A, B, and D-compatible sibling. This was followed by hematological and immunological reconstitution. The hepatic tumors underwent progressive regression after bone marrow transplantation. The patient is now 3 years post-bone marrow transplantation and is in complete remission of his aplastic anemia with no evidence of detectable liver tumors.

Citations

Oct 21, 2004·American Journal of Hematology·Isela Velazquez, Blanche P Alter
Jun 10, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chad R BlystonePaul M D Foster

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