Regressive logistic modeling of familial aggregation for asthma in 7,394 population-based nuclear families

Genetic Epidemiology
M A JenkinsG G Giles

Abstract

The aim of this population-based study was to determine whether asthma aggregates in families, and if so, whether aggregation was consistent with environmental and/or genetic etiologies. Data were from 7,394 nuclear families (41,506 individuals) from the 1968 Tasmanian Asthma Survey, in which all Tasmanian schoolchildren born in 1961 were surveyed by respiratory questionnaire completed by their parents. Similar data were obtained for parents and siblings of probands. For a child, having ever had asthma was predicted by a parent or sibling having ever had asthma; odds ratio (OR) = 3.13 (95% confidence interval [CI] 2.82-3.48) for mother, 2.99 (2.69-3.32) for father, and 3.47 (3.23-3.72) for a sibling. Regressive logistic modeling showed that, in addition to parent-offspring effects, the data were consistent with the existence of an unmeasured factor shared by siblings, evident in 15% (SE 2%) of families and associated with a conditional OR of 9.68 (8.27-11.32). Familial aggregation was best described by a general oligogenic model with non-Mendelian transmission probabilities. Of the Mendelian models, a codominant model with an allele frequency of 16% (SE 0.3%) was preferred. Under a dominant model there was evidence for addition...Continue Reading

References

Jul 1, 1991·Chest·W C MillerD M Suich
Jul 1, 1991·Chest·M M NieminenM Koskenvuo
Jan 1, 1990·Acta geneticae medicae et gemellologiae·J L HopperG G Giles
Dec 1, 1990·The American Review of Respiratory Disease·D L DuffyJ D Mathews
Jan 1, 1990·The American Review of Respiratory Disease·R J HoppN M Nair
Jan 16, 1988·Lancet·W O Cookson, J M Hopkin
Jan 1, 1986·The Journal of Allergy and Clinical Immunology·R G TownleyG D Watt
Aug 1, 1971·Acta Allergologica·M L Edfors-Lubs
Jan 1, 1971·Human Heredity·R C Elston, J Stewart
Jan 1, 1983·Acta geneticae medicae et gemellologiae·M C HannahJ D Mathews
May 1, 1980·Archives of Disease in Childhood·B SibbaldI Gregg
Oct 1, 1994·Annals of Human Genetics·S LawrenceN E Morton
Jul 9, 1994·BMJ : British Medical Journal·M A JenkinsG G Giles
Jan 1, 1993·Paediatric and Perinatal Epidemiology·M A JenkinsG G Giles

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Citations

Jun 15, 2005·Pulmonary Pharmacology & Therapeutics·Stephen T HolgateJohn W Holloway
Dec 10, 1999·American Journal of Respiratory and Critical Care Medicine·X XuS T Weiss
Mar 11, 2000·American Journal of Respiratory and Critical Care Medicine·T LaitinenJ Kere
Oct 8, 2005·American Journal of Respiratory and Critical Care Medicine·Gary M HunninghakeJuan C Celedón
Aug 11, 2007·American Journal of Respiratory and Critical Care Medicine·Craig C TeerlinkLisa A Cannon-Albright
Dec 6, 2007·Chest·Christina V Scirica, Juan C Celedón
Sep 14, 2001·Chest·J C CeledónS T Weiss
Aug 7, 2010·The Journal of Allergy and Clinical Immunology·John W HollowayStephen T Holgate
Mar 11, 2008·The Journal of Allergy and Clinical Immunology·John W HollowayStephen T Holgate
Jun 27, 2006·Paediatric Respiratory Reviews·Adnan Custovic, Angela Simpson
Nov 1, 2005·Annals of Epidemiology·Ke HaoXiping Xu
Oct 7, 2004·The Medical Clinics of North America·Atiya DhalaDavid J Prezant
Jul 30, 2003·Expert Opinion on Therapeutic Targets·Robert M PowellJohn W Holloway
Jun 9, 2016·International Journal of Epidemiology·Melanie C MathesonUNKNOWN TAHS investigator group
Feb 9, 2005·Paediatric Respiratory Reviews·Will Carroll
Jan 21, 2011·Asia-Pacific Journal of Public Health·Gyu-Seok HwangChung-Sik Yoon
Dec 18, 2001·American Journal of Medical Genetics·Y ChenJ A Dosman
Jul 14, 2000·American Journal of Medical Genetics·M Z WamboldtJ Kaprio
Dec 28, 2007·American Journal of Human Biology : the Official Journal of the Human Biology Council·Keydra L PhillipsMichael R DeBaun
May 1, 2008·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Shao LinEdward F Fitzgerald
Aug 26, 1998·Human Mutation·O LevranA D Auerbach
Dec 21, 2002·Immunological Reviews·William Cookson
Jul 14, 2012·Expert Review of Respiratory Medicine·Adnan CustovicAngela Simpson
Feb 13, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·F D Martinez
Sep 14, 2000·Genome Research·L J Palmer, W O Cookson

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