Regular Music Exposure in Juvenile Rats Facilitates Conditioned Fear Extinction and Reduces Anxiety after Foot Shock in Adulthood

BioMed Research International
Si ChenChang-Qi Li

Abstract

Music exposure is known to play a positive role in learning and memory and can be a complementary treatment for anxiety and fear. However, whether juvenile music exposure affects adult behavior is not known. Two-week-old Sprague-Dawley rats were exposed to music for 2 hours daily or to background noise (controls) for a period of 3 weeks. At 60 days of age, rats were subjected to auditory fear conditioning, fear extinction training, and anxiety-like behavior assessments or to anterior cingulate cortex (ACC) brain-derived neurotrophic factor (BDNF) assays. We found that the music-exposed rats showed significantly less freezing behaviors during fear extinction training and spent more time in the open arm of the elevated plus maze after fear conditioning when compared with the control rats. Moreover, the BDNF levels in the ACC in the music group were significantly higher than those of the controls with the fear conditioning session. This result suggests that music exposure in juvenile rats decreases anxiety-like behaviors, facilitates fear extinction, and increases BDNF levels in the ACC in adulthood after a stressful event.

References

Jul 17, 1998·Neurological Research·F H RauscherJ J Jens
Jun 9, 2000·Annual Review of Neuroscience·J E LeDoux
Mar 22, 2001·Nature Reviews. Neuroscience·H van PraagF H Gage
Mar 8, 2002·Nature·Alison Abbott
Nov 9, 2002·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·D K JamesB W Stepsis
Nov 12, 2002·Behavioural Processes·Jaak Panksepp, Günther Bernatzky
Jul 20, 2004·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Christian GoldTony Wigram
Sep 10, 2004·The European Journal of Neuroscience·Giovanni LaviolaRoberta Pacifici
Mar 18, 2005·Nature·Robert Zatorre, James McGill
Sep 21, 2005·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Noura H Al-Qahtani
Dec 29, 2005·Cognition·Sandra E Trehub, Erin E Hannon
Mar 14, 2007·AORN Journal·Felicia VaughnGerry Bosworth
Apr 25, 2007·Nature Reviews. Neuroscience·Nadia TsankovaEric J Nestler
May 26, 2007·Biochemical and Biophysical Research Communications·Hideaki SoyaTakeshi Nishijima
Sep 25, 2007·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Debra S BurnsLarry D Cripe
Aug 12, 2008·Medical Hypotheses·Hajime Fukui, Kumiko Toyoshima
Sep 27, 2008·Neuroscience and Biobehavioral Reviews·Francesca CirulliStephen J Suomi
Jan 20, 2009·Biological Psychiatry·Tania L RothJ David Sweatt
Jun 5, 2010·Science·Jamie PetersGregory J Quirk
Jun 22, 2010·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Yanxia LuFang Pan
Jan 11, 2011·Nature Neuroscience·Valorie N SalimpoorRobert J Zatorre
May 4, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Lauren HowittTimothy V Murphy
Oct 18, 2011·The Clinical Journal of Pain·Stéphane GuétinJacques Touchon
Oct 27, 2011·Yonsei Medical Journal·Dong Soo KimYeo Hoon Yoon
Nov 11, 2011·The Journal of Pain : Official Journal of the American Pain Society·David H BradshawC Richard Chapman
Jan 28, 2012·Pharmacology & Therapeutics·Sivasankaran Balaratnasingam, Aleksandar Janca
Mar 1, 2012·Journal of Physiology and Biochemistry·Inmaculada TassetPedro Montilla
Apr 21, 2012·International Journal of Pediatrics·Karolina PoplawskaPrzemko Kwinta
May 3, 2012·Annals of the New York Academy of Sciences·Sarah M RothmanMark P Mattson

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Methods Mentioned

BETA
ELISA
Enzyme-Linked Immunosorbent Assay
PCR
electrophoresis

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