Regular statin and aspirin use in patients with Barrett's oesophagus is associated with a reduced incidence of oesophageal adenocarcinoma

European Journal of Gastroenterology & Hepatology
Ian L P BealesLeanne Dearman

Abstract

Oesophageal adenocarcinoma (OAC) has a poor prognosis, and chemoprevention is an attractive option to reduce the burden of the disease. Hydroxyl-methyl-CoA reductase inhibitors (statins) have been shown to exert potentially useful anticancer effects against OAC cell lines, but there are only limited clinical data examining the effects of statins on the incidence of OAC. To examine the association between statin use and the incidence of OAC. We have carried out a case-control study comparing statin use between patients with an incident diagnosis of OAC and controls with nonprogressive Barrett's oesophagus. Eighty-five cancer cases were compared with 170 age-matched and sex-matched controls. Risk factors and drug exposure were established using standardized interviews. Logistic regression was used to compare statin exposure and correct for confounding factors. Regular statin use was associated with a significantly lower incidence of OAC [uncorrected odds ratio (OR) 0.45, 95% confidence intervals 0.24-0.84)]. After correction for confounding variables including aspirin and NSAID use, statin use was still associated with a reduced incidence of OAC (OR 0.57, 0.28-0.94). Longer duration of statin use and higher doses were both associ...Continue Reading

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Apr 23, 2013·Current Gastroenterology Reports·Elizabeth Half, Nadir Arber
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