Regularized image reconstruction with an anatomically adaptive prior for positron emission tomography

Physics in Medicine and Biology
Chung ChanSteven Meikle

Abstract

The incorporation of accurately aligned anatomical information as a prior to guide reconstruction and noise regularization in positron emission tomography (PET) has been suggested in many previous studies. However, the advantages of this approach can only be realized if the exact lesion outline is also available. In practice, the anatomical imaging modality may be unable to differentiate between normal and pathological tissues, and thus the edges of lesions seen in the anatomical image may not correspond to functional boundaries in the emission image. In this study, we explored an alternative approach to incorporating an anatomical prior into PET image reconstruction. Of particular interest was the realistic situation where lesions are apparent in the emission images but not in the corresponding anatomical images. In the proposed method, regional information obtained from the anatomical prior was used to estimate an anatomically adaptive anisotropic median-diffusion filtering (AAMDF) prior. This smoothing prior was determined and applied adaptively to each anatomical region on the emission image and then assembled to form a prior image for the next iteration in the reconstruction process. We formulated a two-step joint estimati...Continue Reading

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Citations

Oct 5, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Thomas BeyerHans-Jürgen Wester
Mar 10, 2016·PET Clinics·Kjell ErlandssonBrian F Hutton
Aug 6, 2014·IEEE Transactions on Medical Imaging·Guobao Wang, Jinyi Qi
Mar 7, 2014·IEEE Transactions on Medical Imaging·Chung ChanSteven Meikle
Sep 3, 2016·Medical Physics·Chung ChanChi Liu
Apr 22, 2016·IEEE Transactions on Medical Imaging·Matthias J EhrhardtSimon R Arridge
Dec 22, 2012·Physics in Medicine and Biology·Guanglei ZhangJing Bai
Oct 3, 2018·Physics in Medicine and Biology·Hossein Arabi, Habib Zaidi
Sep 23, 2011·Physics in Medicine and Biology·C TauberI Buvat

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